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Literature summary for 3.4.23.46 extracted from

  • Klaver, D.W.; Wilce, M.C.; Gasperini, R.; Freeman, C.; Juliano, J.P.; Parish, C.; Foa, L.; Aguilar, M.I.; Small, D.H.
    Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimers disease (2010), J. Neurochem., 112, 1552-1561.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
bovine lung heparin 0.0001 mg/ml increases BACE1 activity by 1600% Homo sapiens
heparan sulfate 0.0001 mg/ml increases BACE1 activity by 900% Homo sapiens
heparin heparin can increase the enzyme activity of the partially active zymogen proBACE1 Homo sapiens
additional information heparin disaccharide does not stimulate proBACE1 activity at a concentration of 0.00001-0.1 mg/ml Homo sapiens
mucosal heparin 0.0001 mg/ml increases BACE1 activity by 900%, heparin tetrasaccharide inhibits stimulation of proBACE1 by full-length mucosal heparin at concentrations of greater than 0.0005 mg/ml Homo sapiens
poly-D-glutamic acid 0.0001 mg/ml increases BACE1 activity by 170% Homo sapiens
polysialic acid 0.0001 mg/ml increases BACE1 activity by 160% Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
fragments of amyloid precursor protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
Homo sapiens fragments of amyloid precursor protein
-
?
Mca-SEVNLDAEFRK(2,4-dinitrophenyl)RR-NH2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Homo sapiens
beta-secretase
-
Homo sapiens
beta-site APP cleaving enzyme
-
Homo sapiens

General Information

General Information Comment Organism
metabolism BACE1 is responsible for the first step in the production of the beta-amyloid protein of Alzheimer's disease Homo sapiens