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Literature summary for 3.4.23.46 extracted from

  • Marumoto, S.; Miyazawa, M.
    Biotransformation of bergapten and xanthotoxin by Glomerella cingulata (2010), J. Agric. Food Chem., 58, 7777-7781.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6,7-furano-5,8a-dimethoxy hydrocoumaric acid methyl ester inhibits 57.2% of the BACE1 activity at a concentration of 1 mM Homo sapiens
6,7-furano-5-methoxy hydrocoumaric acid
-
Homo sapiens
6,7-furano-5-methoxy hydrocoumaric acid methyl ester
-
Homo sapiens
6,7-furano-8,8a-dimethoxy hydrocoumaric acid methyl ester inhibits 48.3% of the BACE1 activity at a concentration of 1 mM Homo sapiens
6,7-furano-8-methoxy hydrocoumaric acid
-
Homo sapiens
6,7-furano-8-methoxy hydrocoumaric acid methyl ester inhibits 36.4% of the BACE1 activity at a concentration of 1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
rhodamine-EVNLDAEFK-quencher + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Homo sapiens
beta-secretase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.64
-
in 50 mM sodium acetate, pH 4.5, at 25°C Homo sapiens 6,7-furano-5,8a-dimethoxy hydrocoumaric acid methyl ester