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Literature summary for 3.4.23.46 extracted from

  • Kasturirangan, S.; Boddapati, S.; Sierks, M.R.
    Engineered proteolytic nanobodies reduce Abeta burden and ameliorate Abeta-induced cytotoxicity (2010), Biochemistry, 49, 4501-4508.
    View publication on PubMed

Application

Application Comment Organism
medicine the proteolytic nanobody Asec-1A engineered to cleave amyloid-beta at its alpha-secretase site has potential therapeutic value in the treatment of Alzheimer's disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
Homo sapiens fragments of beta-amyloid precursor protein
-
?
additional information does not cleave phosphoglucose isomerase Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alpha-secretase
-
Homo sapiens
Asec-1A
-
Homo sapiens