Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment. Thiamine supplementation reverses the thiamine deficiency-induced alterations. Thiamine deficiency treatment causes a significant accumulation of reactive oxygen species. Antioxidants suppress reactive oxygen species production and maturation of BACE1, as well as thiamine deficiency-induced amyloid beta accumulation. Exogenous amyloid beta1-40 enhances thiamine deficiency-induced production of reactive oxygen species | Homo sapiens | |
additional information | thiamine deficiency causes amyloid beta accumulation in the brain, which is reversed by thiamine supplementation. Thiamine deficiency can promote beta-secretase activity, and the accumulation of amyloid beta subsequently exacerbates thiamine deficiency-induced oxidative stress | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
C-terminal fragment + soluble N-terminal fragment APPbeta | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
SH-SY5Y cell | in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | C-terminal fragment + soluble N-terminal fragment APPbeta | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
beta-site APP cleaving enzyme 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | thiamine deficiency promotes maturation of BACE1 and increases beta-secretase activity after 3 days | up |