Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.46 extracted from

  • Jo, D.G.; Arumugam, T.V.; Woo, H.N.; Park, J.S.; Tang, S.C.; Mughal, M.; Hyun, D.H.; Park, J.H.; Choi, Y.H.; Gwon, A.R.; Camandola, S.; Cheng, A.; Cai, H.; Song, W.; Markesbery, W.R.; Mattson, M.P.
    Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimers disease (2008), Neurobiol. Aging, 31, 917-925.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner Mus musculus
additional information BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner Homo sapiens
additional information BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease Homo sapiens
additional information gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease Mus musculus
additional information gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain levels of gamma- and beta-secretase activities are greater in brain tissue samples from Alzheimer's disease patients compared to non-demented control subjects Homo sapiens
-
cerebellum
-
Rattus norvegicus
-
cerebral cortical neuron
-
Mus musculus
-
fibroblast immortalized mouse embryonic fibroblasts from wild-type, and presenilin-deficient PS1-/-, PS2-/-, PS1-/-/PS2-/- mice. Oxidative stress fails to induce BACE1 expression in presenilin-1 deficient cells Mus musculus
-
hippocampus
-
Mus musculus
-
neuron
-
Mus musculus
-
parietal lobe
-
Rattus norvegicus
-
SH-SY5Y cell
-
Homo sapiens
-
SH-SY5Y cell oxidative stress fails to induce BACE1 expression in cells treated with gamma-secretase inhibitors. Oxidative stress-induced beta-secretase activity and soluble beta amyloid precursor protein levels are suppressed by gamma-secretase inhibitors Homo sapiens
-

Synonyms

Synonyms Comment Organism
BACE1
-
Mus musculus
BACE1
-
Homo sapiens
BACE1
-
Rattus norvegicus
beta-secretase
-
Mus musculus
beta-secretase
-
Homo sapiens
beta-secretase
-
Rattus norvegicus