Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner | Mus musculus | |
additional information | BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner | Homo sapiens | |
additional information | BACE1 is increased by oxidative stress, oxidative stress fails to induce BACE1 expression in presenilin-1 (gamma-secretase)-deficient cells and in normal cells treated with gamma-secretase inhibitors, 4-hydroxy-2,3-nonenal enhances the expression of BACE1 in a gamma-secretase-dependent manner | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease | Homo sapiens | |
additional information | gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease | Mus musculus | |
additional information | gamma-secretase affects BACE1 expression and induces an increase in protein levels in Alzheimer's disease | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | levels of gamma- and beta-secretase activities are greater in brain tissue samples from Alzheimer's disease patients compared to non-demented control subjects | Homo sapiens | - |
cerebellum | - |
Rattus norvegicus | - |
cerebral cortical neuron | - |
Mus musculus | - |
fibroblast | immortalized mouse embryonic fibroblasts from wild-type, and presenilin-deficient PS1-/-, PS2-/-, PS1-/-/PS2-/- mice. Oxidative stress fails to induce BACE1 expression in presenilin-1 deficient cells | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
parietal lobe | - |
Rattus norvegicus | - |
SH-SY5Y cell | - |
Homo sapiens | - |
SH-SY5Y cell | oxidative stress fails to induce BACE1 expression in cells treated with gamma-secretase inhibitors. Oxidative stress-induced beta-secretase activity and soluble beta amyloid precursor protein levels are suppressed by gamma-secretase inhibitors | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Mus musculus |
BACE1 | - |
Homo sapiens |
BACE1 | - |
Rattus norvegicus |
beta-secretase | - |
Mus musculus |
beta-secretase | - |
Homo sapiens |
beta-secretase | - |
Rattus norvegicus |