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Literature summary for 3.4.23.46 extracted from

  • Faghihi, M.A.; Modarresi, F.; Khalil, A.M.; Wood, D.E.; Sahagan, B.G.; Morgan, T.E.; Finch, C.E.; St Laurent, G.; Kenny, P.J.; Wahlestedt, C.
    Expression of a noncoding RNA is elevated in Alzheimers disease and drives rapid feed-forward regulation of beta-secretase (2008), Nat. Med., 14, 723-730.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information upon exposure to various cell stressors including amyloid-beta 1-42, expression of BACE1-antisense transcript becomes elevated leading to increased BACE1 mRNA stability. BACE1 expression by BACE1-antisense transcript does not occur only at the mRNA but also at the protein level. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. Mus musculus
additional information upon exposure to various cell stressors including amyloid-beta 1-42, expression of BACE1-antisense transcript becomes elevated leading to increased BACE1 mRNA stability. BACE1 expression by BACE1-antisense transcript does not occur only at the mRNA but also at the protein level. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. Homo sapiens

Application

Application Comment Organism
medicine the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 1-42 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in subjects with Alzheimer's disease Homo sapiens
medicine the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 142 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in amyloid precursor protein transgenic mice Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 1-42 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in subjects with Alzheimer's disease Homo sapiens
additional information the BACE1-antisense transcript regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. Upon exposure to various cell stressors including amyloid-beta 1-42 , expression of BACE1-antisense becomes elevated, increasing BACE1 mRNA stability and generating additional amyloid beta 142 through a post-transcriptional feed-forward mechanism. BACE1-antisense concentrations are elevated in amyloid precursor protein transgenic mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
Homo sapiens
-
cerebral cortical neuron
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Mus musculus
-
cerebral cortical neuron
-
Homo sapiens
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
parietal lobe
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
BACE1
-
Mus musculus
BACE1
-
Homo sapiens
beta-secretase-1
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Mus musculus
beta-secretase-1
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Homo sapiens