BRENDA - Reference to 3.4.23.45; Id = 669916

DNA and amino acid sequence analysis, 5'-flanking region analysis, BACE2 mapping to chromosome 21q22.3, expression analysis, sequence comparison to BACE1

Homo sapiens

beta-amyloid precursor protein APP + H2O

Homo sapiens

-

beta-amyloid protein + beta-amyloid precursor protein pre-peptide

-

?

Homo sapiens

-

brain

-

Homo sapiens

-

additional information

tissue-type specific expression, BACE2 expression is high in peripheral tissues and in brain regions including the postcentral gyrus and temporal lobes

Homo sapiens

-

beta-amyloid precursor protein APP + H2O

-

669916

Homo sapiens

beta-amyloid protein + beta-amyloid precursor protein pre-peptide

-

?

DNA and amino acid sequence analysis, 5'-flanking region analysis, BACE2 mapping to chromosome 21q22.3, expression analysis, sequence comparison to BACE1

Homo sapiens

beta-amyloid precursor protein APP + H2O

Homo sapiens

-

beta-amyloid protein + beta-amyloid precursor protein pre-peptide

-

?

brain

-

Homo sapiens

-

additional information

tissue-type specific expression, BACE2 expression is high in peripheral tissues and in brain regions including the postcentral gyrus and temporal lobes

Homo sapiens

-

beta-amyloid precursor protein APP + H2O

-

669916

Homo sapiens

beta-amyloid protein + beta-amyloid precursor protein pre-peptide

-

?

735274

Mirsafian

Amino acid sequence and struct ...

Homo sapiens

ScientificWorldJournal

2014

482463

2014

-

1

-

1

-

1

-

734208

Stuetzer

Systematic proteomic analysis ...

Mus musculus

J. Biol. Chem.

288

10536-10547

2013

-

1

-

1

-

1

-

1

-

1

-

734521

van Bebber

Loss of Bace2 in zebrafish aff ...

Danio rerio

J. Neurochem.

127

471-481

2013

-

3

-

1

-

1

-

1

-

735167

Rochin

BACE2 processes PMEL to form t ...

Mus musculus

Proc. Natl. Acad. Sci. USA

110

10658-10663

2013

-

1

-

3

-

1

-

1

-

1

-

1

-

733057

Holler

BACE2 expression increases in ...

Homo sapiens

Am. J. Pathol.

180

337-350

2012

-

1

-

2

-

1

-

734728

Abdul-Hay

Identification of BACE2 as an ...

Homo sapiens

Mol. Neurodegener.

7

46

2012

-

1

-

1

-

1

-

1

-

1

-

717461

Esterhazy

Bace2 is a beta cell-enriched ...

Mus musculus

Cell Metab.

14

365-377

2011

-

1

-

4

-

5

-

1

-

1

-

5

-

1

-

1

-

717979

Al-Tel

Design, synthesis, and qualita ...

Homo sapiens

J. Med. Chem.

54

8373-8385

2011

-

1

-

3

-

1

-

1

-

3

-

3

-

1

-

3

-

1

-

1

-

711696

Castorina

Early effects of aluminum chlo ...

Homo sapiens

Cell Biol. Toxicol.

26

367-377

2010

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

3

1

3

-

712811

Ahmed

BACE1 and BACE2 enzymatic acti ...

Homo sapiens

J. Neurochem.

112

1045-1053

2010

-

1

-

2

-

1

-

1

-

1

-

717072

Casas

BACE2 plays a role in the insu ...

Homo sapiens

Am. J. Physiol. Endocrinol. Metab.

299

E1087-E1095

2010

-

2

-

1

-

1

-

1

-

717636

Azkona

Characterization of a mouse mo ...

Homo sapiens

Genes Brain Behav.

9

160-172

2010

-

1

-

4

-

1

-

1

-

712825

Vassar

The beta-secretase enzyme BACE ...

Homo sapiens

J. Neurosci.

29

12787-12794

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

697442

Venugopal

beta-Secretase: structure, fun ...

Homo sapiens

CNS Neurol. Disord. Drug Targets

7

278-294

2008

-

2

-

1

-

1

-

683144

Stockley

The proteins BACE1 and BACE2 a ...

Homo sapiens

Biochem. Soc. Trans.

35

574-576

2007

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

684385

Cheon

Protein expression of BACE1, B ...

Homo sapiens

Amino Acids

35

339-343

2007

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

687544

Kuhn

Regulated intramembrane proteo ...

Homo sapiens

J. Biol. Chem.

282

11982-11995

2007

-

1

-

2

-

3

-

6

-

1

-

2

-

6

-

669871

Ostermann

Crystal structure of human BAC ...

Homo sapiens

J. Mol. Biol.

355

249-261

2006

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

669915

Lahiri

Functional domains of the BACE ...

Homo sapiens

J. Mol. Neurosci.

29

65-80

2006

-

1

-

2

-

2

-

2

-

2

1

-

1

-

2

-

2

-

2

1

-

669916

Maloney

Characterization of the human ...

Homo sapiens

J. Mol. Neurosci.

29

81-99

2006

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

2

-

1

-

683469

Stockley

Altered beta-secretase enzyme ...

Homo sapiens, Rattus norvegicus

FEBS Lett.

580

6550-6560

2006

-

1

-

1

-

2

-

2

-

1

-

2

-

3

2

-

1

-

1

-

1

-

2

-

2

-

3

2

-

686629

Sun

BACE2, as a novel APP theta-se ...

Homo sapiens

FASEB J.

20

1369-1376

2006

-

1

-

1

-

1

-

4

-

1

-

1

-

8

-

2

-

1

-

1

-

1

-

1

-

8

-

2

-

668810

Tang

-

Memapsin 1 ...

Homo sapiens

Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )

1

64-66

2004

-

1

-

2

-

1

-

1

-

8

-

3

1

-

1

-

1

-

2

-

1

-

8

-

3

1

-

1

-

670020

Chou

Insights from modeling the ter ...

Homo sapiens

J. Proteome Res.

3

1069-1072

2004

-

1

-

1

-

2

-

2

-

3

1

-

1

-

1

-

2

-

3

1

-

638898

Li

beta-Amyloid secretases and be ...

Mus musculus, Mus musculus C57B16/J, Rattus norvegicus

Mol. Vis.

9

179-183

2003

-

1

-

5

-

2

-

1

-

2

-

638902

Vattemi

BACE1 and BACE2 in pathologic ...

Homo sapiens

Exp. Neurol.

179

150-158

2003

-

2

-

2

-

3

-

2

-

3

-

638895

Fluhrer

A non-amyloidogenic function o ...

Homo sapiens

J. Neurochem.

81

1011-1020

2002

-

1

-

1

-

3

-

2

1

-

1

-

1

-

2

-

1

-

1

-

3

-

2

1

-

1

-

2

-

638897

Kim

Enzymic properties of recombin ...

Homo sapiens

Eur. J. Biochem.

269

5668-5677

2002

-

1

-

2

1

-

1

-

2

-

1

-

1

-

11

-

1

-

3

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

11

-

1

-

3

-

1

-

638899

Motonaga

Elevated expression of beta-si ...

Homo sapiens

Neurosci. Lett.

326

64-66

2002

-

1

-

2

-

3

-

2

-

1

-

3

-

2

-

638901

Turner

Specificity of memapsin 1 and ...

Homo sapiens

Biochemistry

41

8742-8746

2002

-

3

-

1

-

2

-

2

-

3

-

1

-

2

-

638896

Ghosh

Structure-based design: potent ...

Homo sapiens

J. Med. Chem.

44

2865-2868

2001

-

1

-

2

-

1

-

1

-

1

-

2

-

2

-

1

-

2

-

1

-

1

-

2

-

638894

Farzan

BACE2, a beta -secretase homol ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

97

9712-9717

2000

-

1

-

1

-

1

-

2

-

1

-

6

-

3

-

1

-

1

-

1

-

1

-

2

-

6

-

3

-

1

-

638900

Solans

A new aspartyl protease on 21q ...

Homo sapiens

Cytogenet. Cell Genet.

89

177-184

2000

-

1

-

3

-

1

-

7

-

2

-

2

-

14

-

638903

Hussain

ASP1 (BACE2) cleaves the amylo ...

Homo sapiens

Mol. Cell. Neurosci.

16

609-619

2000

-

1

-

2

-

2

1

-

1

-

1

-

5

-

3

-

1

-

2

-

2

1

-

1

-

5

-

3

-

Characterization of the human beta-secretase 2 (BACE2) 5-flanking region: identification of a 268-bp region as the basal BACE2 promoter

Data extracted from this reference: