BRENDA - Enzyme Database show
show all sequences of 3.4.23.45

beta-Amyloid secretases and beta-amyloid degrading enzyme expression in lens

Li, G.; Percontino, L.; Sun, Q.; Qazi, A.S.; Frederikse, P.H.; Mol. Vis. 9, 179-183 (2003)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
56000
-
SDS-PAGE
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
C57/B16
-
Mus musculus C57B16/J
-
C57/B16
-
Rattus norvegicus
-
Sprague Dawley
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
lens
-
Mus musculus
-
lens
-
Rattus norvegicus
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
56000
-
SDS-PAGE
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
lens
-
Mus musculus
-
lens
-
Rattus norvegicus
-
Other publictions for EC 3.4.23.45
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735274
Mirsafian
Amino acid sequence and struct ...
Homo sapiens
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Systematic proteomic analysis ...
Mus musculus
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van Bebber
Loss of Bace2 in zebrafish aff ...
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J. Neurochem.
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2013
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735167
Rochin
BACE2 processes PMEL to form t ...
Mus musculus
Proc. Natl. Acad. Sci. USA
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10658-10663
2013
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733057
Holler
BACE2 expression increases in ...
Homo sapiens
Am. J. Pathol.
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2012
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734728
Abdul-Hay
Identification of BACE2 as an ...
Homo sapiens
Mol. Neurodegener.
7
46
2012
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1
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717461
Esterhazy
Bace2 is a beta cell-enriched ...
Mus musculus
Cell Metab.
14
365-377
2011
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717979
Al-Tel
Design, synthesis, and qualita ...
Homo sapiens
J. Med. Chem.
54
8373-8385
2011
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3
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1
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3
3
3
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1
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711696
Castorina
Early effects of aluminum chlo ...
Homo sapiens
Cell Biol. Toxicol.
26
367-377
2010
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1
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3
1
1
3
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712811
Ahmed
BACE1 and BACE2 enzymatic acti ...
Homo sapiens
J. Neurochem.
112
1045-1053
2010
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1
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717072
Casas
BACE2 plays a role in the insu ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
299
E1087-E1095
2010
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1
1
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717636
Azkona
Characterization of a mouse mo ...
Homo sapiens
Genes Brain Behav.
9
160-172
2010
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1
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1
1
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712825
Vassar
The beta-secretase enzyme BACE ...
Homo sapiens
J. Neurosci.
29
12787-12794
2009
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697442
Venugopal
beta-Secretase: structure, fun ...
Homo sapiens
CNS Neurol. Disord. Drug Targets
7
278-294
2008
-
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1
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683144
Stockley
The proteins BACE1 and BACE2 a ...
Homo sapiens
Biochem. Soc. Trans.
35
574-576
2007
-
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1
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1
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684385
Cheon
Protein expression of BACE1, B ...
Homo sapiens
Amino Acids
35
339-343
2007
-
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687544
Kuhn
Regulated intramembrane proteo ...
Homo sapiens
J. Biol. Chem.
282
11982-11995
2007
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1
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3
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6
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1
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6
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669871
Ostermann
Crystal structure of human BAC ...
Homo sapiens
J. Mol. Biol.
355
249-261
2006
-
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1
1
1
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1
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1
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3
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1
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1
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1
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669915
Lahiri
Functional domains of the BACE ...
Homo sapiens
J. Mol. Neurosci.
29
65-80
2006
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1
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2
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1
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1
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669916
Maloney
Characterization of the human ...
Homo sapiens
J. Mol. Neurosci.
29
81-99
2006
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683469
Stockley
Altered beta-secretase enzyme ...
Homo sapiens, Rattus norvegicus
FEBS Lett.
580
6550-6560
2006
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1
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2
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686629
Sun
BACE2, as a novel APP theta-se ...
Homo sapiens
FASEB J.
20
1369-1376
2006
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1
1
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4
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8
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1
1
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8
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2
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668810
Tang
-
Memapsin 1 ...
Homo sapiens
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
64-66
2004
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1
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1
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670020
Chou
Insights from modeling the ter ...
Homo sapiens
J. Proteome Res.
3
1069-1072
2004
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1
1
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2
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1
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638898
Li
beta-Amyloid secretases and be ...
Mus musculus, Mus musculus C57B16/J, Rattus norvegicus
Mol. Vis.
9
179-183
2003
-
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-
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1
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5
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638902
Vattemi
BACE1 and BACE2 in pathologic ...
Homo sapiens
Exp. Neurol.
179
150-158
2003
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2
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638895
Fluhrer
A non-amyloidogenic function o ...
Homo sapiens
J. Neurochem.
81
1011-1020
2002
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1
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11
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638899
Motonaga
Elevated expression of beta-si ...
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Neurosci. Lett.
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64-66
2002
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638901
Turner
Specificity of memapsin 1 and ...
Homo sapiens
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2002
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Ghosh
Structure-based design: potent ...
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2001
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2
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638894
Farzan
BACE2, a beta -secretase homol ...
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2000
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6
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Solans
A new aspartyl protease on 21q ...
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2000
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638903
Hussain
ASP1 (BACE2) cleaves the amylo ...
Homo sapiens
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2000
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