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Literature summary for 3.4.23.45 extracted from

  • Fluhrer, R.; Capell, A.; Westmeyer, G.; Willem, M.; Hartung, B.; Condron, M.M.; Teplow, D.B.; Haass, C.; Walter, J.
    A non-amyloidogenic function of BACE-2 in the secretory pathway (2002), J. Neurochem., 81, 1011-1020.
    View publication on PubMed
Search for more literature for 3.4.23.45

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK 293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
brefeldin A strongly inhibits cleavage of amyloid-beta precursor protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
Golgi apparatus
-
 Homo sapiens 5794
-
plasma membrane enzyme is poorly reinternalized into membrane Homo sapiens 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
 non glycosylated, SDS-PAGE Homo sapiens
65000
-
 glycosylated, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
amyloid-beta precursor protein + H2O cleaves in the middle of the amyloid-beta protein domain between Phe19 and Phe20, resulting in increased secretion of amyloid precursor proteins-alpha- and p3-like products Homo sapiens ?
-
 ?