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Literature summary for 3.4.23.45 extracted from

  • Farzan, M.; Schnitzler, C.E.; Vasilieva, N.; Leung, D.; Choe, H.
    BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein (2000), Proc. Natl. Acad. Sci. USA, 97, 9712-9717.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.45

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
R310Lys mutation interferes with the ability of the enzyme to cleave at the beta site of amyloid-beta precursor protein, but not at their respective cleavage sites internal to amyloid-beta protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information M617V mutation in amyloid-beta precursor protein inhibits BACE2 beta-site cleavage Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens BACE2 cleaves at the beta site and more efficiently at a different site within amyloid-beta precursor protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
medulla oblongata
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
spinal cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
amyloid-beta precursor protein + H2O cleaves after the Phe19 and Phe20 Homo sapiens ?
-
 ?
additional information BACE2 cleaves at the beta site and more efficiently at a different site within amyloid-beta precursor protein Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Homo sapiens