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Literature summary for 3.4.23.40 extracted from

  • Castanheira, P.; Samyn, B.; Sergeant, K.; Clemente, J.C.; Dunn, B.M.; Pires, E.; Van Beeumen, J.; Faro, C.
    Activation, proteolytic processing, and peptide specificity of recombinant cardosin A (2005), J. Biol. Chem., 280, 13047-13054.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D32A active site mutant, inactive, no processing of proenzyme Cynara cardunculus

Inhibitors

Inhibitors Comment Organism Structure
pepstatin
-
Cynara cardunculus
pepstatin A
-
Cynara cardunculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
L-Lys-L-Pro-L-Ala-L-Glu-L-Phe-L-Phe(NO2)-L-Ala-L-Leu 37°C, pH 7.4 Cynara cardunculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
11000
-
x * 47000, and x * 37000, processing intermediates, x * 26000 + x * 11000, associated by disulfide bridge, mature enzyme, SDS-PAGE Cynara cardunculus
26000
-
x * 47000, and x * 37000, processing intermediates, x * 26000 + x * 11000, associated by disulfide bridge, mature enzyme, SDS-PAGE Cynara cardunculus
37000
-
x * 47000, and x * 37000, processing intermediates, x * 26000 + x * 11000, associated by disulfide bridge, mature enzyme, SDS-PAGE Cynara cardunculus
47000
-
x * 47000, and x * 37000, processing intermediates, x * 26000 + x * 11000, associated by disulfide bridge, mature enzyme, SDS-PAGE Cynara cardunculus

Organism

Organism UniProt Comment Textmining
Cynara cardunculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification autocatalytic processing, optimal processing at pH 4.0 Cynara cardunculus

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
Cynara cardunculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Lys-L-Pro-L-Ala-L-Glu-L-Phe-L-Phe(NO2)-L-Ala-L-Leu + H2O
-
Cynara cardunculus ?
-
?
additional information preference for phenylalanine, leucine or norleucine at P! site, for tyrosine or phenylalanine at P1’ site Cynara cardunculus ?
-
?

Subunits

Subunits Comment Organism
? x * 47000, and x * 37000, processing intermediates, x * 26000 + x * 11000, associated by disulfide bridge, mature enzyme, SDS-PAGE Cynara cardunculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40 45
-
Cynara cardunculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
65
-
L-Lys-L-Pro-L-Ala-L-Glu-L-Phe-L-Phe(NO2)-L-Ala-L-Leu 37°C, pH 7.4 Cynara cardunculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 4.5
-
Cynara cardunculus

pH Range

pH Minimum pH Maximum Comment Organism
2.5 6
-
Cynara cardunculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000001
-
pepstatin 37°C, pH 7.4 Cynara cardunculus