Inhibitors | Comment | Organism | Structure |
---|---|---|---|
extract from Plexaura homomalla | black sea rod, extract contains a reversible tight-binding inhibitor | Plasmodium falciparum | |
extract from Xestospongia muta | giant barrel sponge, extract contains a reversible tight-binding inhibitor | Plasmodium falciparum | |
additional information | generation of an affinity matrix for purification of natural inhibitors by immobilization of the recombinant proenzyme to N-hydroxysuccinimide-activated Sepharose and the activation of the immobilized enzyme by incubation at pH 4.4 and 37°C. The matrices are useful in the affinity purification of the inhibitory activity detected in marine invertebrates, such as Xestospongia muta, giant barrel sponge, and the gorgonian seafan coral Plexaura homomalla, with increases of 10.2- and 5.9fold in the specific inhibitory activity, respectively | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0274 | - |
Leu-Ser-Phe(NO2)-Nle-Ala-Leu-Ome | pH 4.4, 37°C | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10.4 | - |
Leu-Ser-Phe(NO2)-Nle-Ala-Leu-Ome | pH 4.4, 37°C | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000019 | - |
extract from Plexaura homomalla | pH 4.4, 37°C | Plasmodium falciparum | |
0.0000464 | - |
extract from Xestospongia muta | pH 4.4, 37°C | Plasmodium falciparum |