Literature summary for 3.4.23.39 extracted from

Istvan, E.S.; Goldberg, D.E.
Distal substrate interactions enhance plasmepsin activity (2005), J. Biol. Chem., 280, 6890-6896.

Search for more literature for 3.4.23.39

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Plasmodium falciparum
0.001	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.001	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	mature enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00105	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	autoactivated enzyme	Plasmodium falciparum
0.00127	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244A mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00138	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244E mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00233	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244K mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00294	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00302	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244E mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00305	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	autoactivated enzyme	Plasmodium falciparum
0.00386	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	mature enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00433	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244A mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.00611	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244K mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O	-	Plasmodium falciparum	?	-	?
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O	-	Plasmodium falciparum	?	-	?
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O	-	Plasmodium falciparum	?	-	?
Hemoglobin + H2O	cleaves native hemoglobin and loosely folded alpha-chain	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
plasmepsin II	-	Plasmodium falciparum
PM II	-	Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Plasmodium falciparum
0.431	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244E mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.596	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.845	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244K mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.875	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	mature enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
0.952	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244E mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
1.05	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
1.1	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	autoactivated enzyme	Plasmodium falciparum
1.11	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244A mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
1.51	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244K mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
2.33	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	mature enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
2.51	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244A mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
2.52	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	autoactivated enzyme	Plasmodium falciparum
6.08	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum
6.08	-	4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid	F244K mutant enzyme expressed by a system that bypasses the need for autoactivation	Plasmodium falciparum

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Release 2023.1 (January 2023)