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Literature summary for 3.4.23.39 extracted from

  • Dame, J.B.; Reddy, G.R.; Yowell, C.A.; Dunn, B.M.; Kay, J.; Berry, C.
    Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmidum falciparum (1994), Mol. Biochem. Parasitol., 64, 177-190.
    View publication on PubMed
Search for more literature for 3.4.23.39

Cloned(Commentary)

Cloned (Comment) Organism
expression as a glutathione-S-transferase-proteinase fusion construct in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-5-trimethylsilyl-pent-2-en-4-ynyl]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum
pepstatin
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole digestive vacuole Plasmodium falciparum 5773
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36924
-
 x * 36924, calculation from nucleotide sequence Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Plasmodium falciparum the enzyme participates in the hemoglobin digestive pathway ?
-
 ?
Hemoglobin + H2O Plasmodium falciparum HB3 the enzyme participates in the hemoglobin digestive pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Plasmodium falciparum HB3
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O the enzyme participates in the hemoglobin digestive pathway Plasmodium falciparum ?
-
 ?
Hemoglobin + H2O the enzyme participates in the hemoglobin digestive pathway Plasmodium falciparum HB3 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 36924, calculation from nucleotide sequence Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
 Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
4 5.5 pH 4.0: about 40% of maximal activity, pH 5.5: about 10% of maximal activity Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
 (2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-5-trimethylsilyl-pent-2-en-4-ynyl]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum