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Literature summary for 3.4.23.38 extracted from

  • Thillainayagam, M.; Malathi, K.; Anbarasu, A.; Singh, H.; Bahadur, R.; Ramaiah, S.
    Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives - Molecular docking and comparative molecular field analysis (2019), J. Biomol. Struct. Dyn., 37, 3168-3182 .
    View publication on PubMed
Search for more literature for 3.4.23.38

Inhibitors

Inhibitors Comment Organism Structure
(1S,2aR,3aR,3bS,4R,9aR,11aS)-2-(((1-(2-cyanophenyl)-1H-1,2,3-triazol-4-yl)methoxy)imino)-1-(furan-3-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1,2,2a,3b,4,5,5a,6,7,9a,9b,10,11,11a-tetradecahydronaphtho(1,2':6,7)indeno(1,7a-b)oxiren-4-yl acetate most active compound Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Plasmodium falciparum
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum P39898
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
 Plasmodium falciparum ?
-
 ?

Synonyms

Synonyms Comment Organism
PM-I
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0017
-
 pH and temperature not specified in the publication Plasmodium falciparum (1S,2aR,3aR,3bS,4R,9aR,11aS)-2-(((1-(2-cyanophenyl)-1H-1,2,3-triazol-4-yl)methoxy)imino)-1-(furan-3-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1,2,2a,3b,4,5,5a,6,7,9a,9b,10,11,11a-tetradecahydronaphtho(1,2':6,7)indeno(1,7a-b)oxiren-4-yl acetate