Literature summary for 3.4.23.38 extracted from

Moon, R.P.; Bur, D.; Loetscher, H.; D'Arcy, A.; Tyas, L.; Oefner, C.; Grueninger-Leitch, F.; Mona, D.; Rupp, K.; Dorn, A.; Matile, H.; Certa, U.; Berry, C.; Kay, J.; Ridley, R.G.
Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets (1998), Adv. Exp. Med. Biol., 436, 397-406.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	plasmepsin I is a valid antimalarial drug target on two counts. First, inhibition of the enzyme correlates with inhibition of parasite growth. Second, specificity of inhibition over human aspartic proteinases is possible	Plasmodium falciparum
Ro40-4388	-	Plasmodium falciparum
Ro40-5576	-	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000008	-	Ro40-5576	-	Plasmodium falciparum
0.000009	-	Ro40-4388	-	Plasmodium falciparum

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Release 2023.1 (January 2023)