BRENDA - Reference to 3.4.23.38; Id = 648184

membrane

proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form

Plasmodium falciparum

16020

-

vacuole

-

Plasmodium falciparum

5773

-

additional information

Plasmodium falciparum

plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell

?

-

Plasmodium falciparum

-

proteolytic modification

proplasmepsin maturation appears to require acidic conditions, proplasmepsin maturation may not be autocatalytic in vivo

Plasmodium falciparum

additional information

plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell

648184

Plasmodium falciparum

?

-

membrane

proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form

Plasmodium falciparum

16020

-

vacuole

-

Plasmodium falciparum

5773

-

additional information

Plasmodium falciparum

plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell

?

-

proteolytic modification

proplasmepsin maturation appears to require acidic conditions, proplasmepsin maturation may not be autocatalytic in vivo

Plasmodium falciparum

additional information

plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell

648184

Plasmodium falciparum

?

-

718040

Bhaumik

Crystal structures of the free ...

Plasmodium falciparum

J. Struct. Biol.

175

73-84

2011

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

696329

Liu

Recombinant plasmepsin 1 from ...

Plasmodium falciparum

Biochemistry

48

4086-99

2009

-

1

-

8

3

-

4

-

1

-

4

-

3

1

-

8

-

1

-

8

3

-

1

-

4

-

3

1

-

707169

Moura

Role of Plasmodium falciparum ...

Plasmodium falciparum

Antimicrob. Agents Chemother.

53

4968-4978

2009

-

1

-

1

-

1

-

1

-

708121

Friedman

Discovery of plasmepsin inhibi ...

Plasmodium falciparum

ChemMedChem

4

1317-1326

2009

-

14

-

1

-

1

-

14

-

14

-

1

-

680251

Bonilla

Effects on growth, hemoglobin ...

Plasmodium falciparum

Int. J. Parasitol.

37

317-327

2007

-

1

-

2

-

1

-

1

-

1

-

682004

Bonilla

Critical roles for the digesti ...

Plasmodium falciparum

Mol. Microbiol.

65

64-75

2007

-

3

-

4

-

3

-

682637

Xiao

Expression and enzymatic chara ...

Plasmodium falciparum

Protein Eng. Des. Sel.

20

625-633

2007

-

1

-

1

-

4

-

1

-

2

-

3

-

2

-

1

-

1

2

-

1

-

2

-

3

-

667927

Ersmark

Macrocyclic inhibitors of the ...

Plasmodium falciparum

Bioorg. Med. Chem.

14

2197-2208

2006

-

4

-

3

-

4

-

4

-

670126

Ersmark

Plasmepsins as potential targe ...

Plasmodium falciparum

Med. Res. Rev.

26

626-666

2006

-

29

-

5

-

29

-

29

-

677552

Hof

Starving the malaria parasite: ...

Plasmodium falciparum

Angew. Chem.

45

2138-2141

2006

-

4

-

1

-

4

-

4

-

679228

Boss

Achiral, cheap, and potent inh ...

Plasmodium falciparum

ChemMedChem

1

1341-1345

2006

-

13

-

1

-

13

-

13

-

681296

DellAgli

High antiplasmodial activity o ...

Plasmodium falciparum

J. Med. Chem.

49

7440-7449

2006

-

11

-

3

-

2

-

1

-

10

-

10

-

10

11

10

-

2

-

1

-

669779

Johansson

Design and synthesis of potent ...

Plasmodium falciparum

J. Med. Chem.

48

4400-4409

2005

-

17

-

3

-

16

-

17

16

-

648181

Ersmark

Potent inhibitors of the Plasm ...

Plasmodium falciparum

J. Med. Chem.

47

110-122

2004

-

17

-

3

-

1

-

15

-

17

15

-

1

-

669770

Johansson

Design and synthesis of potent ...

Plasmodium falciparum

J. Med. Chem.

47

3353-3366

2004

-

22

-

3

-

21

-

22

21

-

648183

Dahlgren

New inhibitors of the malaria ...

Plasmodium falciparum

Bioorg. Med. Chem.

11

3423-3437

2003

-

12

-

2

-

3

-

12

3

-

648186

Noteberg

Design and synthesis of plasme ...

Plasmodium falciparum

J. Med. Chem.

46

734-746

2003

-

12

-

3

-

3

-

1

-

12

-

12

-

3

-

1

-

648187

Siripurkpong

Active Site Contribution to Sp ...

Plasmodium falciparum

J. Biol. Chem.

277

41009-41013

2002

-

2

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

2

1

-

1

-

1

-

2

-

1

-

648182

Berry

Plasmepsins as antimalarial ta ...

Plasmodium falciparum

Curr. Opin. Drug Discov. Devel.

3

624-629

2000

-

3

-

1

-

1

-

2

-

3

2

-

1

-

648188

Tyas

Naturally-occurring and recomb ...

Plasmodium falciparum

FEBS Lett.

454

210-214

1999

-

3

10

-

3

-

5

-

9

-

5

-

3

5

10

-

5

-

9

-

648185

Moon

Studies on plasmepsins I and I ...

Plasmodium falciparum

Adv. Exp. Med. Biol.

436

397-406

1998

-

3

-

1

-

2

-

3

2

-

648189

Tyas

Plasmepsins I and II from the ...

Plasmodium falciparum

Adv. Exp. Med. Biol.

436

407-411

1998

-

1

-

3

2

-

1

-

1

-

4

-

2

1

-

3

-

1

-

3

2

-

1

-

4

-

2

1

-

648184

Francis

Biosynthesis and maturation of ...

Plasmodium falciparum

J. Biol. Chem.

272

14961-14968

1997

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

648190

Moon

Expression and characterizatio ...

Plasmodium falciparum

Eur. J. Biochem.

244

552-560

1997

-

1

-

1

-

4

2

-

3

-

1

-

1

-

3

-

2

1

-

4

-

1

-

1

-

4

2

-

1

-

1

-

3

-

2

1

-

648179

Francis

Molecular characterization and ...

Plasmodium falciparum

EMBO J.

13

306-317

1994

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

648180

Gluzman

Order and specificity of the P ...

Plasmodium falciparum

J. Clin. Invest.

93

1602-1608

1994

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

648178

Goldberg

Hemoglobin degradation in the ...

Plasmodium falciparum

J. Exp. Med.

173

961-969

1991

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

3

2

-

1

-

1

-

1

-

1

-

1

-

Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II

Data extracted from this reference: