Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z-LL)2-ketone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
FKBP8 + H2O | Homo sapiens | i.e. SCSLVLEHQPDNIK | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FKBP8 + H2O | i.e. SCSLVLEHQPDNIK | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Signal peptide peptidase | - |
Homo sapiens |
SPP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression is highly induced in human lung and breast cancers | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme downregulation suppresses tumor cell colony formation, migration, and invasion in vitro | Homo sapiens |
physiological function | the enzyme promotes tumor progression via facilitating FKBP8 degradation | Homo sapiens |