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Literature summary for 3.4.23.36 extracted from

  • Hsu, F.F.; Chou, Y.T.; Chiang, M.T.; Li, F.A.; Yeh, C.T.; Lee, W.H.; Chau, L.Y.
    Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation (2019), Oncogene, 38, 1688-1701 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(Z-LL)2-ketone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
FKBP8 + H2O Homo sapiens i.e. SCSLVLEHQPDNIK ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
NCI-H1299 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FKBP8 + H2O i.e. SCSLVLEHQPDNIK Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Signal peptide peptidase
-
Homo sapiens
SPP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is highly induced in human lung and breast cancers up

General Information

General Information Comment Organism
malfunction enzyme downregulation suppresses tumor cell colony formation, migration, and invasion in vitro Homo sapiens
physiological function the enzyme promotes tumor progression via facilitating FKBP8 degradation Homo sapiens