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Literature summary for 3.4.23.36 extracted from

  • Niemeyer, J.; Mentrup, T.; Heidasch, R.; Mueller, S.A.; Biswas, U.; Meyer, R.; Papadopoulou, A.A.; Dederer, V.; Haug-Kroeper, M.; Adamski, V.; Luellmann-Rauch, R.; Bergmann, M.; Mayerhofer, A.; Saftig, P.; Wennemuth, G.; Jessberger, R.; Fluhrer, R.; Lichtenthaler, S.F.; Lemberg, M.K.; Schroeder, B.
    The intramembrane protease SPPL2c promotes male germ cell development by cleavingphospholamban (2019), EMBO Rep., 20, e46449 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.36

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme oxygenase 1 + H2O Mus musculus
-
 ?
-
 ?
additional information Mus musculus no activity with tumor necrosis factor-alpha, neuregulin 1 type III and Bri2 ?
-
 ?
phospholamban + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatid
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme oxygenase 1 + H2O
-
 Mus musculus ?
-
 ?
additional information no activity with tumor necrosis factor-alpha, neuregulin 1 type III and Bri2 Mus musculus ?
-
 ?
phospholamban + H2O
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
SPPL2c
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to a partial loss of elongated spermatids and reduced motility of mature spermatozoa, but preserved fertility Mus musculus
physiological function the enzyme promotes male germ cell development by cleavingxa0phospholamban Mus musculus