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Literature summary for 3.4.23.34 extracted from

  • Harada, Y.; Zhang, J.; Imari, K.; Yamasaki, R.; Ni, J.; Wu, Z.; Yamamoto, K.; Kira, J.I.; Nakanishi, H.; Hayashi, Y.
    Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis (2019), Pain, 160, 2050-2062 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O Mus musculus
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?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
CatE
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus MOG35-55 directly binds to toll-like receptor 4, which leads to increased production of the enzyme in neutrophils down

General Information

General Information Comment Organism
malfunction enzyme-deficient mice are highly resistant to myelin oligodendrocyte glycoprotein 35-55-induced mechanical allodynia Mus musculus
physiological function cathepsin E in neutrophils contributes to the generation of mechanical allodynia in experimental autoimmune encephalomyelitis. The enzyme is required for the enzymatic activity of elastase in neutrophils after myelin oligodendrocyte glycoprotein 35-55 stimulation Mus musculus