Literature summary for 3.4.23.34 extracted from

Cruz-Monserrate, Z.; Abd-Elgaliel, W.; Grote, T.; Deng, D.; Ji, B.; Arumugam, T.; Wang, H.; Tung, C.; Logsdon, C.
Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models (2012), Gut, 61, 1315-1322.

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Application

Application	Comment	Organism
medicine	pancreas-bearing pancreatic intraepithelial neoplasia lesions and pancreatic tumours show an elevated expression of cathepsin E, allowing selective in-vivo detection of human pancreatic ductal adenocarcinoma xenografts and imaging of pancreas with pancreatic intraepithelial neoplasia lesions and pancreatic tumours in genetically engineered mouse models of pancreatic cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	pancreas from normal, chronic pancreatitis and pancreatic ductal adenocarcinoma patients	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	cathepsin E mRNA is highly upregulated in a human pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia lesions as well as in genetically engineered mouse models of pancreatic cancer	up

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Release 2023.1 (January 2023)