Literature summary for 3.4.23.34 extracted from

Kitamura, K.; Yoshida, C.; Kinoshita, Y.; Kadowaki, T.; Takahashi, Y.; Tayama, T.; Kawakubo, T.; Naimuddin, M.; Salimullah, M.; Nemoto, N.; Hanada, K.; Husimi, Y.; Yamamoto, K.; Nishigaki, K.
Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E (2009), J. Mol. Biol., 387, 1186-1198.

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Inhibitors

Inhibitors	Comment	Organism	Structure
DGCCIIIIGGRPPTHLFLD	-	Rattus norvegicus
DGCCIIINGGRPPTVFFRVKDYKHHDDK	-	Rattus norvegicus
GCGGLLPFGGQPPNPLF	-	Rattus norvegicus
GGRPIIIIGG	-	Rattus norvegicus
GGSCSSCLGGRPPTIFFRLKDYKDDDDK	-	Rattus norvegicus
IIIISCIGDDGHQKKKK	-	Rattus norvegicus
NDDKIIIICCII	-	Rattus norvegicus
NDDKIIIIPTIFGG	-	Rattus norvegicus
NYKDSCIG	-	Rattus norvegicus
pepstatin A	-	Rattus norvegicus
SCGGIIIISCIA	-	Rattus norvegicus
SCIGIIDSGGRPPTIFFRAEGLQR	-	Rattus norvegicus
SGLLFRLKGG	-	Rattus norvegicus
YCGGLLPLGGRPPTIFFRLKDYKGDDDK	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P16228	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
MOCAc-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(DnP)-D-Arg-NH2 + H2O	-	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin E	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000003	-	NYKDSCIG	non-competitive	Rattus norvegicus
0.000005	-	SCGGIIIISCIA	non-competitive	Rattus norvegicus
0.000014	-	NDDKIIIICCII	competitive	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00023	-	-	Rattus norvegicus	SCGGIIIISCIA
0.00024	-	-	Rattus norvegicus	GGSCSSCLGGRPPTIFFRLKDYKDDDDK
0.00024	-	-	Rattus norvegicus	IIIISCIGDDGHQKKKK
0.00026	-	-	Rattus norvegicus	NDDKIIIIPTIFGG
0.00028	-	-	Rattus norvegicus	NDDKIIIICCII
0.00032	-	-	Rattus norvegicus	SGLLFRLKGG
0.00038	-	-	Rattus norvegicus	YCGGLLPLGGRPPTIFFRLKDYKGDDDK
0.00068	-	-	Rattus norvegicus	NYKDSCIG
0.00084	-	-	Rattus norvegicus	GCGGLLPFGGQPPNPLF
0.0012	-	-	Rattus norvegicus	DGCCIIINGGRPPTVFFRVKDYKHHDDK
0.0046	-	-	Rattus norvegicus	GGRPIIIIGG

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Release 2023.1 (January 2023)