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Literature summary for 3.4.23.34 extracted from
- Purification and characterization of cathepsin E type acid proteinase from gastric mucosa of bullfrog, Rana catesbeiana (1994), J. Biochem., 115, 76-81.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pepstatin | - |
Lithobates catesbeianus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid composition | Lithobates catesbeianus |
| additional information | - |
procathepsin E of human or guinea pig, frog pepsinogen or procathepsin D of rat and human | Lithobates catesbeianus |
| 45000 | - |
2 * 45000, procathepsin E, SDS-PAGE, reducing conditions | Lithobates catesbeianus |
| 88000 | - |
Rana catesbeiana, gel filtration | Lithobates catesbeianus |
| 90000 | - |
procathepsin E, SDS-PAGE, non-reducing conditions | Lithobates catesbeianus |
| 90000 | - |
Rana catesbeiana | Lithobates catesbeianus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lithobates catesbeianus | - |
bull frog | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Lithobates catesbeianus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Lithobates catesbeianus | - |
| stomach | - |
Lithobates catesbeianus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Lithobates catesbeianus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Bovine gamma-globulin + H2O | pH 2.5, at 2.3% the rate of hemoglobin hydrolysis | Lithobates catesbeianus | Hydrolyzed bovine gamma-globulin | - |
? | |
| Bovine serum albumin + H2O | pH 2.5 at 14% the rate of hemoglobin hydrolysis | Lithobates catesbeianus | Hydrolyzed bovine serum albumin | - |
? | |
| casein + H2O | at 2.3% the rate of hemoglobin hydrolysis | Lithobates catesbeianus | hydrolyzed casein | - |
? | |
| Hemoglobin + H2O | preferred substrate | Lithobates catesbeianus | Hydrolyzed hemoglobin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | SDS-PAGE, reducing conditions | Lithobates catesbeianus |
| dimer | 2 * 45000, procathepsin E, SDS-PAGE, reducing conditions | Lithobates catesbeianus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 2 | 3.5 | hemoglobin as substrate | Lithobates catesbeianus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 1.6 | 3.9 | half-maximal activity at pH 1.6 and 3.9, hemoglobin as substrate | Lithobates catesbeianus |
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