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Literature summary for 3.4.23.25 extracted from
- Analysis of a processing system for proteases using yeast cell surface engineering: conversion of precursor of proteinase A to active proteinase A (2006), Appl. Microbiol. Biotechnol., 72, 1229-1237.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| construction of different PEP4, PRB1, and PRC1 deficiency mutants | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vacuole | mature protein | Saccharomyces cerevisiae | 5773 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procarboxypeptidase Y + H2O | Saccharomyces cerevisiae | maturation and activation of procarboxypeptidase Y | propeptide of carboxypeptidase Y + carboxypeptidase Y | - |
? |  |
| procarboxypeptidase Y + H2O | Saccharomyces cerevisiae MT8-1 | maturation and activation of procarboxypeptidase Y | propeptide of carboxypeptidase Y + carboxypeptidase Y | - |
? | |
| proproteinase A + H2O | Saccharomyces cerevisiae | autocatalytic activation of proproteinase A | propeptide of proteinase A + proteinase A | - |
? | |
| proproteinase A + H2O | Saccharomyces cerevisiae MT8-1 | autocatalytic activation of proproteinase A | propeptide of proteinase A + proteinase A | - |
? | |
| proproteinase B + H2O | Saccharomyces cerevisiae | maturation and activation of proproteinase B | propeptide of proteinase B + proteinase B | - |
? | |
| proproteinase B + H2O | Saccharomyces cerevisiae MT8-1 | maturation and activation of proproteinase B | propeptide of proteinase B + proteinase B | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
wild type and PEP4, PRB1, and PRC1 deficiency mutants | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procarboxypeptidase Y + H2O | maturation and activation of procarboxypeptidase Y | Saccharomyces cerevisiae | propeptide of carboxypeptidase Y + carboxypeptidase Y | - |
? | |
| procarboxypeptidase Y + H2O | maturation and activation of procarboxypeptidase Y | Saccharomyces cerevisiae MT8-1 | propeptide of carboxypeptidase Y + carboxypeptidase Y | - |
? | |
| proproteinase A + H2O | autocatalytic activation of proproteinase A | Saccharomyces cerevisiae | propeptide of proteinase A + proteinase A | - |
? | |
| proproteinase A + H2O | autocatalytic activation of proproteinase A | Saccharomyces cerevisiae MT8-1 | propeptide of proteinase A + proteinase A | - |
? | |
| proproteinase B + H2O | maturation and activation of proproteinase B | Saccharomyces cerevisiae | propeptide of proteinase B + proteinase B | - |
? | |
| proproteinase B + H2O | maturation and activation of proproteinase B | Saccharomyces cerevisiae MT8-1 | propeptide of proteinase B + proteinase B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pep4 | - |
Saccharomyces cerevisiae |
| PEP4 gene product | PEP4 gene encodes the inactive preproenzyme | Saccharomyces cerevisiae |
| PRA | - |
Saccharomyces cerevisiae |
| Proteinase A | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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