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Literature summary for 3.4.23.25 extracted from

  • Cronin, N.B.; Badasso, M.O.; Tickle, J.; Dreyer, T.; Hoover, D.J.; Rosati, R.L.; Humblet, C.C.; Lunney, E.A.; Cooper, J.B.
    X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity (2000), J. Mol. Biol., 303, 745-760.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
vapour diffusion, space group P3(2)21, in complex with inhibitor CP-81,198 unit cell dimensions a : b : 86.8 A, c : 110.2 A, in complex with inhibitor CP-108,420 unit cell dimensions a : b : 86.9 A, c : 110.2 A, in complex with inhibitor CP-72,647 unit cell dimensions a : b : 86.4 A, c : 109.9 A, in complex with inhibitor PD-129,541 unit cell dimensions a : b : 87.3 A, c : 110.7 A, in complex with inhibitor PD-133,450 unit cell dimensions a : b : 86.9 A, c : 110.2 A Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
CP-108,420
-
Saccharomyces cerevisiae
CP-72,647
-
Saccharomyces cerevisiae
CP-81,198
-
Saccharomyces cerevisiae
CP-81,282
-
Saccharomyces cerevisiae
PD-129,541 cyclic peptide inhibitor Saccharomyces cerevisiae
PD-133,450
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
baker's yeast
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
haemoglobin + H2O
-
Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Proteinase A
-
Saccharomyces cerevisiae
vacuolar aspartic proteinase
-
Saccharomyces cerevisiae
yeast proteinase
-
Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3
-
for haemoglobin cleavage Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000004
-
PD-129,541 pH 4.7, 37°C Saccharomyces cerevisiae
0.0000071
-
CP-81,282 pH 4.7, 37°C Saccharomyces cerevisiae
0.0000137
-
PD-133,450 pH 4.7, 37°C Saccharomyces cerevisiae
0.000398
-
CP-108,420 pH 4.7, 37°C Saccharomyces cerevisiae
0.0009418
-
CP-81,198 pH 4.7, 37°C Saccharomyces cerevisiae
0.003742
-
CP-72,647 pH 4.7, 37°C Saccharomyces cerevisiae