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Literature summary for 3.4.23.25 extracted from

  • Phylip, L.H.; Lees, W.E.; Brownsey, B.G.; Bur, D.; Dunn, B.M.; Winther, J.R.; Gustchina, A.; Li, M.; Copeland, T.; Wlodawer, A.; Kay, J.
    The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae (2001), J. Biol. Chem., 276, 2023-2030.
    View publication on PubMed

Application

Application Comment Organism
medicine participates in a variety of physiological processes, and the onset of pathological conditions such as hypertension, gastric ulcers, and neoplastic diseases may be related to changes in the level of activity Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
IA3 inhibitor
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Lys-Pro-Ile-Glu-Phe-(NO2)Phe-Arg-Leu + H2O
-
Saccharomyces cerevisiae Lys-Pro-Ile-Glu-Phe + (NO2)Phe-Arg-Leu
-
?

Synonyms

Synonyms Comment Organism
Aspartic proteinase
-
Saccharomyces cerevisiae
Proteinase A
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000006
-
IA3 inhibitor pH 4.7, 37°C, D22L inhibitor and synthetic peptide form 24 inhibitor Saccharomyces cerevisiae
0.0000008
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 4 inhibitor and synthetic peptide form 9-NH2 inhibitor Saccharomyces cerevisiae
0.0000009
-
IA3 inhibitor pH 3.1, 37°C, K31M/K32mutant inhibitor Saccharomyces cerevisiae
0.000001
-
IA3 inhibitor pH 4.7, 37°C, (Gly)9 inhibitor and synthetic peptide form 24 inhibitor Saccharomyces cerevisiae
0.0000011
-
IA3 inhibitor pH 3.1, 37°C, wild-type inhibitor Saccharomyces cerevisiae
0.0000013
-
IA3 inhibitor pH 3.1, 37°C, K24mutant inhibitor Saccharomyces cerevisiae
0.000002
-
IA3 inhibitor pH 3.1, 37°C, K7mutant inhibitor and synthetic peptide form 2 inhibitor, pH 4.7, synthetic peptide form 9 inhibitor and synthetic peptide 10-NH2 inhibitor Saccharomyces cerevisiae
0.000003
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 1 inhibitor and synthetic peptide form 3 inhibitor Saccharomyces cerevisiae
0.0000035
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 21 inhibitor Saccharomyces cerevisiae
0.000004
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 4 inhibitor Saccharomyces cerevisiae
0.000005
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 9-NH2 inhibitor, pH 4.7, 37°C, synthetic peptide form 10 inhibitor Saccharomyces cerevisiae
0.000006
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 5 inhibitor Saccharomyces cerevisiae
0.000007
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 16 inhibitor Saccharomyces cerevisiae
0.0000075
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 22 inhibitor Saccharomyces cerevisiae
0.0000076
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 23 inhibitor Saccharomyces cerevisiae
0.000008
-
IA3 inhibitor pH 3.1, 37°C, chimera inhibitor, D22L inhibitor, synthetic peptide form 5 inhibitor, and synthetic peptide 10-NH2 inhibitor, pH 4.7, 37°C, synthetic peptide form 15 inhibitor Saccharomyces cerevisiae
0.000015
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 6 inhibitor and synthetic peptide form 25 inhibitor Saccharomyces cerevisiae
0.0000175
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 21 inhibitor Saccharomyces cerevisiae
0.00002
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 22 inhibitor and synthetic peptide form 23 inhibitor Saccharomyces cerevisiae
0.000025
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 10 inhibitor Saccharomyces cerevisiae
0.000029
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 9 inhibitor Saccharomyces cerevisiae
0.00004
-
IA3 inhibitor pH 3.1, 37°C, (Gly)9 inhibitor, pH 4.7, 37°C, synthetic peptide form 25 inhibitor Saccharomyces cerevisiae
0.00005
-
IA3 inhibitor pH 4.7, 37°C, MIX inhibitor Saccharomyces cerevisiae
0.000055
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 17 inhibitor Saccharomyces cerevisiae
0.00006
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 16 inhibitor, pH 4.7, 37°C, synthetic peptide form 11-NH2 inhibitor Saccharomyces cerevisiae
0.00007
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 15 inhibitor, pH 4.7, 37°C, synthetic peptide form 27 inhibitor Saccharomyces cerevisiae
0.000085
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 6 inhibitor Saccharomyces cerevisiae
0.00024
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 11-NH2 inhibitor Saccharomyces cerevisiae
0.00033
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 18 inhibitor Saccharomyces cerevisiae
0.0004
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 11 inhibitor, pH 3.1, synthetic peptide form 17 inhibitor Saccharomyces cerevisiae
0.0005
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 7 inhibitor Saccharomyces cerevisiae
0.0007
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 11 inhibitor Saccharomyces cerevisiae
0.0008
-
IA3 inhibitor pH 3.1, 37°C, MIX inhibitor, pH 4.7, 37°C, synthetic peptide form 19 inhibitor Saccharomyces cerevisiae
0.001
-
IA3 inhibitor pH 4.7, 37°C, synthetic peptide form 12 inhibitor Saccharomyces cerevisiae
0.0021
-
IA3 inhibitor pH 3.1, 37°C, synthetic peptide form 18 inhibitor Saccharomyces cerevisiae