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Literature summary for 3.4.23.24 extracted from

  • Singh, D.; Nemeth, T.; Papp, A.; Toth, R.; Lukacsi, S.; Heidingsfeld, O.; Dostal, J.; Vagvoelgyi, C.; Bajtay, Z.; Jozsi, M.; Gacser, A.
    Functional characterization of secreted aspartyl proteases in Candida parapsilosis (2019), mSphere, 4, e00484-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.24

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component 3b + H2O Candida parapsilosis substrate for isoforms Sapp1p and Sapp2p ?
-
 ?
complement component 4b + H2O Candida parapsilosis substrate for isoforms Sapp1p and Sapp2p ?
-
 ?
factor H + H2O Candida parapsilosis substrate for isoforms Sapp1p and Sapp2p ?
-
 ?
factor H-related protein 5 + H2O Candida parapsilosis substrate for isoform Sapp2p ?
-
 ?

Organism

Organism UniProt Comment Textmining
Candida parapsilosis P32951
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component 3b + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ?
-
 ?
complement component 4b + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ?
-
 ?
factor H + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ?
-
 ?
factor H-related protein 5 + H2O substrate for isoform Sapp2p Candida parapsilosis ?
-
 ?

Synonyms

Synonyms Comment Organism
SAPP1 isoform Candida parapsilosis
SAPP2 isoform Candida parapsilosis
SAPP3 isoform Candida parapsilosis
secreted aspartyl protease
-
 Candida parapsilosis

General Information

General Information Comment Organism
physiological function isoforms SAPP1 and SAPP2, but not SAPP3, influence adhesion, host cell damage, phagosome-lysosome maturation, phagocytosis, killing capacity, and cytokine secretion by hu-man peripheral blood-derived macrophages Candida parapsilosis