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Literature summary for 3.4.23.24 extracted from
- Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response (2018), J. Biol. Chem., 293, 6410-6433 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
[Candida] glabrata | 9986 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| [Candida] glabrata | - |
- |
- |
| [Candida] glabrata BG2 | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspartyl protease | - |
[Candida] glabrata |
| yapsin | - |
[Candida] glabrata |
| Yps | - |
[Candida] glabrata |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the Cgyps1-11 mutant lacking all 11 enzyme genes displays pleiotropic defects, including increased susceptibility to cell wall and osmotic stress, perturbed vacuole and pH homeostasis, and attenuated intracellular survival and pathogenesis | [Candida] glabrata |
| physiological function | the enzyme is required for suppression of the host innate immune response by suppressing the interleukin-1production in macrophages. The enzyme genes are required for organ colonization and dissemination in a mouse model of systemic infection | [Candida] glabrata |
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Release 2023.1 (January 2023)
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