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Literature summary for 3.4.23.24 extracted from

  • Kumar, R.; Saraswat, D.; Tati, S.; Edgerton, M.
    Novel aggregation properties of Candida albicans secreted aspartyl proteinase SAP6 mediate virulence in oral candidiasis (2015), Infect. Immun., 83, 2614-2626 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans Q5AC08
-
-
Candida albicans CAI4 Q5AC08
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE Sephadex A-25 gel filtration and hydroxyapatite column chromatography Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fluorescein-labeled casein + H2O
-
 Candida albicans ?
-
 ?
fluorescein-labeled casein + H2O
-
 Candida albicans CAI4 ?
-
 ?

Synonyms

Synonyms Comment Organism
SAP6
-
 Candida albicans
secreted aspartyl proteinase
-
 Candida albicans

General Information

General Information Comment Organism
physiological function secreted aspartyl proteinase Sap6 mediates virulence in oral candidiasis. Mice infected sublingually with Candida albicans cells overexpressing Sap6 have thicker fungal plaques and more severe oral infection Candida albicans