BRENDA - Enzyme Database
show all sequences of 3.4.23.23

Kinetic studies on the action of Mucor pusillus, Mucor miehei acid proteases and chymosins A and B on a synthetic chromophoric hexapeptide

Martin, P.; Raymond, M.N.; Bricas, E.; Dumas, B.R.; Biochim. Biophys. Acta 612, 410-420 (1980)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Rhizomucor miehei
additional information
-
additional information
-
Rhizomucor pusillus
Organism
Organism
UniProt
Commentary
Textmining
Rhizomucor miehei
-
-
-
Rhizomucor pusillus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Kappa-casein + H2O
-
30652
Rhizomucor miehei
Hydrolyzed kappa-casein
-
30652
Rhizomucor miehei
-
Kappa-casein + H2O
-
30652
Rhizomucor pusillus
Hydrolyzed kappa-casein
-
30652
Rhizomucor pusillus
-
additional information
milk clotting activity
30652
Rhizomucor miehei
?
-
-
-
-
additional information
milk clotting activity
30652
Rhizomucor pusillus
?
-
-
-
-
Peptides + H2O
-
30652
Rhizomucor miehei
Hydrolyzed peptides
-
30652
Rhizomucor miehei
-
Peptides + H2O
-
30652
Rhizomucor pusillus
Hydrolyzed peptides
-
30652
Rhizomucor pusillus
-
Proteins + H2O
involving aromatic residues
30652
Rhizomucor miehei
Hydrolyzed proteins
-
30652
Rhizomucor miehei
-
Proteins + H2O
involving aromatic residues
30652
Rhizomucor pusillus
Hydrolyzed proteins
-
30652
Rhizomucor pusillus
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
49
55
Mucor pusillus
Rhizomucor pusillus
63
-
above, Mucor miehei
Rhizomucor miehei
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Rhizomucor miehei
additional information
-
additional information
-
Rhizomucor pusillus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.7
-
-
Rhizomucor miehei
4.7
-
-
Rhizomucor pusillus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Rhizomucor miehei
additional information
-
additional information
-
Rhizomucor pusillus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Kappa-casein + H2O
-
30652
Rhizomucor miehei
Hydrolyzed kappa-casein
-
30652
Rhizomucor miehei
-
Kappa-casein + H2O
-
30652
Rhizomucor pusillus
Hydrolyzed kappa-casein
-
30652
Rhizomucor pusillus
-
additional information
milk clotting activity
30652
Rhizomucor miehei
?
-
-
-
-
additional information
milk clotting activity
30652
Rhizomucor pusillus
?
-
-
-
-
Peptides + H2O
-
30652
Rhizomucor miehei
Hydrolyzed peptides
-
30652
Rhizomucor miehei
-
Peptides + H2O
-
30652
Rhizomucor pusillus
Hydrolyzed peptides
-
30652
Rhizomucor pusillus
-
Proteins + H2O
involving aromatic residues
30652
Rhizomucor miehei
Hydrolyzed proteins
-
30652
Rhizomucor miehei
-
Proteins + H2O
involving aromatic residues
30652
Rhizomucor pusillus
Hydrolyzed proteins
-
30652
Rhizomucor pusillus
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
49
55
Mucor pusillus
Rhizomucor pusillus
63
-
above, Mucor miehei
Rhizomucor miehei
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Rhizomucor miehei
additional information
-
additional information
-
Rhizomucor pusillus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.7
-
-
Rhizomucor miehei
4.7
-
-
Rhizomucor pusillus
Other publictions for EC 3.4.23.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752456
Kangwa
Identification and characteri ...
Mucor circinelloides, Mucor circinelloides DSM 2183
AMB Express
8
157
2018
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
4
1
2
1
-
1
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
4
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
743030
da Silva
Evaluation of the catalytic s ...
Rhizomucor miehei
J. Ind. Microbiol. Biotechnol.
43
1059-1069
2016
-
-
-
-
-
-
4
7
-
5
-
-
-
1
-
-
-
-
-
-
1
-
8
1
-
1
2
1
6
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
4
-
7
-
5
-
-
-
-
-
-
-
-
1
-
8
1
1
2
1
6
1
1
1
-
-
-
-
-
7
7
754256
Nascimento
Purification of a fibrinolyti ...
Mucor subtilissimus, Mucor subtilissimus UCP 1262
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1025
16-24
2016
-
-
-
-
-
-
9
-
-
4
-
-
-
3
-
-
1
-
-
-
-
-
8
1
1
1
1
1
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1
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-
-
9
-
-
-
4
-
-
-
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-
1
-
-
-
-
8
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
754970
Yuqiu
-
Screening and characterizatio ...
Rhizomucor pusillus
Open Biotechnol. J.
9
119-126
2015
-
-
1
-
9
-
11
-
-
4
-
-
-
1
-
-
1
-
-
-
-
-
2
1
3
1
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
9
-
-
11
-
-
-
4
-
-
-
-
-
1
-
-
-
-
2
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
755331
Zhang
-
Structure-based design of Muc ...
Rhizomucor pusillus
Protein Pept. Lett.
22
660-667
2015
-
-
-
-
3
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717133
Yegin
Aspartic proteinases from Muco ...
Amylomyces rouxii, Aspergillus oryzae, Cryphonectria parasitica, Mucor bacilliformis, Mucor circinelloides, Mucor hiemalis, Mucor racemosus f. racemosus, Mucor renninus, Penicillium duponti, Rhizomucor miehei, Rhizomucor pusillus, Rhizopus oryzae
Appl. Microbiol. Biotechnol.
89
949-960
2011
-
-
-
-
-
-
12
-
-
-
7
-
-
12
-
-
-
-
-
-
-
-
48
10
36
7
-
-
-
12
-
-
-
-
7
-
-
-
-
-
-
-
-
-
12
-
-
-
-
7
-
-
-
-
-
-
-
-
-
48
10
7
-
-
-
12
-
-
7
-
-
-
-
-
-
717060
Yegin
-
Production of extracellular as ...
Mucor mucedo, Mucor mucedo DSM 809
Afr. J. Biotechnol.
9
6380-6386
2010
-
-
-
-
-
-
-
-
1
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-
2
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2
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1
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1
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-
-
2
-
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-
-
-
-
-
-
-
-
-
-
-
667045
Badasso
Crystallization and X-ray anal ...
Rhizomucor pusillus
Acta Crystallogr. Sect. D
60
770-772
2004
-
-
-
1
1
-
1
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
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1
1
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1
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
650661
Beldarrain
-
Characterization of Mucor pusi ...
Rhizomucor pusillus
Biotechnol. Appl. Biochem.
31
77-84
2000
-
1
1
-
-
-
-
-
-
-
1
1
-
1
-
1
1
-
-
-
-
-
1
1
2
-
-
1
-
1
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
1
-
-
-
-
1
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
649247
Yang
-
Structure of the Rhizomucor mi ...
Rhizomucor miehei
Acta Crystallogr. Sect. D
D55
625-630
1999
-
-
-
1
-
-
1
-
-
-
-
-
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1
-
-
1
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-
-
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-
2
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1
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1
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1
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-
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-
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-
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-
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-
-
-
653000
Fernandez-Lahore
Purification and characterizat ...
Mucor sp., Mucor sp. M-105
J. Pept. Res.
53
599-605
1999
-
1
-
-
-
-
2
1
-
-
2
2
-
2
-
-
1
-
-
-
-
-
4
1
1
2
-
1
-
1
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1
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1
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-
-
-
-
-
2
-
1
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-
2
2
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-
1
-
-
-
-
4
1
2
-
1
-
1
-
-
1
-
-
-
-
-
-
649270
Quail
Crystal structure of the Rhizo ...
Rhizomucor miehei
Adv. Exp. Med. Biol.
436
283-292
1998
-
1
-
1
-
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1
-
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-
1
1
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1
-
1
1
-
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-
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2
-
2
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-
1
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1
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1
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1
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1
1
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1
1
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-
-
-
2
-
-
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-
-
1
-
-
-
-
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-
-
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-
653147
Murakami
-
Structure of asparagine-linked ...
Rhizomucor pusillus
Microbiology
144
1369-1374
1998
-
-
-
-
-
-
-
-
-
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1
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1
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1
1
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2
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3
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1
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1
1
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2
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652776
Yang
Crystal structure of the aspar ...
Rhizomucor miehei
J. Mol. Biol.
268
449-459
1997
-
-
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1
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1
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1
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2
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1
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1
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30680
Fernandez Lahore
-
Partition behavior and purific ...
Mucor bacilliformis
Process Biochem.
30
615-621
1995
-
-
-
-
-
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1
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1
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30682
Newman
X-ray analyses of aspartic pro ...
Rhizomucor pusillus
J. Mol. Biol.
230
260-283
1993
-
-
-
1
-
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5
-
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1
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30643
Drohse
Specificity of milk-clotting e ...
Rhizomucor miehei
Biochim. Biophys. Acta
995
221-224
1989
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1
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2
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30681
Baudys
Protein chemical characterizat ...
Rhizomucor pusillus
FEBS Lett.
235
271-274
1988
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1
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1
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1
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-
30644
Yamashita
Secretion of Mucor rennin, a f ...
Rhizomucor pusillus
Mol. Gen. Genet.
210
462-467
1987
-
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1
-
-
-
-
-
-
-
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4
-
1
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-
-
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1
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1
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1
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1
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30645
Murata
-
Studies on the coagulation of ...
Rhizomucor miehei
Agric. Biol. Chem.
51
385-389
1987
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1
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1
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-
30589
Dunn
A systematic series of synthet ...
Rhizomucor miehei, Rhizomucor pusillus
Biochem. J.
237
899-906
1986
-
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4
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2
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4
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2
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4
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4
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-
2
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30646
Gray
Primary structure of Mucor mie ...
Rhizomucor miehei
Gene
48
41-53
1986
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1
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30647
Tonouchi
Cloning and sequencing of a ge ...
Rhizomucor pusillus
Nucleic Acids Res.
14
7557-7568
1986
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3
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30649
Khan
Partial purification of Mucor ...
Rhizomucor pusillus
Appl. Environ. Microbiol.
45
94-96
1983
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1
1
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2
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2
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2
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2
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1
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1
1
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-
2
-
2
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2
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2
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30650
Ethoh
Photo-oxidation of a histidyl ...
Rhizomucor pusillus
J. Biochem.
91
747-753
1982
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1
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1
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1
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30651
Fraile
-
Milk-clotting enzyme from Muco ...
Mucor bacilliformis
Eur. J. Appl. Microbiol. Biotechnol.
13
191-193
1981
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1
-
1
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-
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-
-
-
-
1
-
1
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30652
Martin
Kinetic studies on the action ...
Rhizomucor miehei, Rhizomucor pusillus
Biochim. Biophys. Acta
612
410-420
1980
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2
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8
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2
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2
2
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2
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8
-
2
-
-
2
2
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-
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30653
Belyauskaite
-
Purification and some properti ...
Mucor renninus
Enzyme Microb. Technol.
2
37-44
1980
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-
-
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1
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1
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1
1
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-
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1
1
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-
-
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-
1
-
-
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1
1
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-
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-
-
-
-
-
-
-
1
1
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-
-
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30654
Khan
Extracellular proteases of Muc ...
Rhizomucor pusillus
Appl. Environ. Microbiol.
37
719-724
1979
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1
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1
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1
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1
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2
-
1
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-
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-
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-
1
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-
-
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1
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-
1
-
-
-
1
-
2
-
1
-
-
-
-
-
-
-
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30655
Etoh
-
Milk-clotting enzyme from micr ...
Rhizomucor miehei, Rhizomucor pusillus
Agric. Biol. Chem.
43
209-215
1979
-
-
-
-
-
-
-
-
-
-
2
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-
2
-
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2
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-
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2
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-
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-
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-
-
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30656
Rickert
Structural and functional dete ...
Rhizomucor miehei
Biochim. Biophys. Acta
480
262-274
1977
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-
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3
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1
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3
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-
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30568
Takahashi
The structure and function of ...
Rhizomucor pusillus
J. Biochem.
80
497-506
1976
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-
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3
-
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1
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3
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-
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-
30658
Takahshi
The structure and function of ...
Rhizomucor pusillus
J. Biochem.
80
61-67
1976
-
-
-
-
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3
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-
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-
1
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3
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-
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30659
Ledward
Structural and functional dete ...
Rhizomucor miehei
Biochim. Biophys. Acta
379
426-430
1975
-
-
-
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-
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-
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1
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1
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-
-
-
-
-
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1
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-
-
1
-
-
-
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
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30660
Rickert
Structural and functional dete ...
Rhizomucor miehei
Biochim. Biophys. Acta
371
368-378
1974
-
-
-
-
-
-
1
-
-
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-
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1
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-
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-
-
-
-
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-
1
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-
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-
-
-
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-
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-
-
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30661
Rickert
-
Structural and functional dete ...
Rhizomucor miehei
Biochim. Biophys. Acta
336
437-444
1974
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-
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1
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1
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1
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30566
Morihara
Comparative specificity of mic ...
Rhizomucor miehei
Arch. Biochem. Biophys.
157
561-572
1973
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3
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-
-
-
3
-
-
-
-
-
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-
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30641
Rickert
Acid proteases from species of ...
Rhizomucor miehei
Can. J. Biochem.
51
1638-1646
1973
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1
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1
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1
1
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-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
30663
Oka
-
Specificity of a Renninlike en ...
Rhizomucor pusillus
Agric. Biol. Chem.
37
1177-1184
1973
-
-
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1
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2
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-
-
2
-
-
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-
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30664
Oka
Comparative specificity of mic ...
Rhizomucor miehei
Arch. Biochem. Biophys.
156
552-559
1973
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1
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3
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-
-
-
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-
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-
-
-
-
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-
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-
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-
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-
-
-
3
-
-
-
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-
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30665
Oka
Comparative specificity of mic ...
Rhizomucor miehei
Arch. Biochem. Biophys.
156
543-551
1973
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1
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-
-
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
-
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30666
Sanner
Kinetic studies on the aggrega ...
Rhizomucor pusillus
Biochim. Biophys. Acta
303
68-76
1973
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-
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1
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1
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1
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2
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-
-
-
-
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-
-
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-
-
-
-
-
-
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-
1
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-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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30667
Sternberg
Bond specificity, active site ...
Rhizomucor miehei
Biochim. Biophys. Acta
285
383-392
1972
-
-
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2
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9
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2
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9
-
-
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-
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-
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30669
Rickert
Structural and functional dete ...
Rhizomucor miehei
Biochim. Biophys. Acta
271
93-101
1972
-
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1
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-
-
-
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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30670
Takahshi
Inactivation of acid proteases ...
Rhizomucor pusillus
J. Biochem.
71
161-164
1972
-
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1
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1
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-
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-
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-
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-
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-
-
-
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-
1
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-
-
-
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-
-
-
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-
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30671
Yu
-
Milk-clotting enzyme from micr ...
Rhizomucor pusillus
Agric. Biol. Chem.
35
1398-1401
1971
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1
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1
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30672
Yu
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Milk-clotting enzyme from micr ...
Rhizomucor pusillus
Agric. Biol. Chem.
35
1194-1199
1971
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1
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1
1
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-
-
-
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-
-
-
-
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-
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1
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1
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-
-
-
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-
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30674
Voynick
The comparative specificity of ...
Rhizomucor miehei
Proc. Natl. Acad. Sci. USA
68
257-259
1971
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1
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1
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1
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1
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1
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30642
Ottesen
The isolation and partial char ...
Rhizomucor miehei
C. R. Trav. Lab. Carlsberg
37
301-325
1970
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1
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1
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1
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1
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30668
Arima
-
Milk-clotting enzyme for Mucor ...
Rhizomucor pusillus
Methods Enzymol.
19
446-459
1970
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11
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2
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1
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1
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2
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2
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1
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1
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1
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11
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2
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3
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1
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30673
Ottesen
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Acid protease of Mucor miehei ...
Rhizomucor miehei
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459-460
1970
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1
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2
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1
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1
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30676
Yu
Milk-clotting enzyme from micr ...
Rhizomucor pusillus
Biochim. Biophys. Acta
171
138-144
1969
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2
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30675
Arima
Milk-clotting enzyme from micr ...
Rhizomucor pusillus
Appl. Microbiol.
16
1727-1733
1968
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1
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4
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3
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1
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4
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1
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30677
Yu
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Release of sialic acid from ka ...
Rhizomucor pusillus
Agric. Biol. Chem.
32
1482-1483
1968
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1
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30678
Yu
-
The active site of Mucor-renni ...
Rhizomucor pusillus
Agric. Biol. Chem.
32
1048-1050
1968
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1
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1
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1
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30679
Somkuti
Purification and properties of ...
Rhizomucor pusillus
J. Bacteriol.
95
1407-1414
1968
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7
1
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7
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