Literature summary for 3.4.23.22 extracted from

Mondal, M.; Groothuis, D.; Hirsch, A.
Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin (2015), MedChemComm, 6, 1267-1271 .

No PubMed abstract available

Search for more literature for 3.4.23.22

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-2-amino-2-[4-(trifluoromethyl)phenyl]-N'-[(E)-[3-(trifluoromethyl)phenyl]methylidene]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-2-[4-(trifluoromethyl)phenyl]-N'-[(E)-[4-(trifluoromethyl)phenyl]methylidene]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-N'-[(1E)-2-methylbutylidene]-2-[4-(trifluoromethyl)phenyl]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(2-hydroxy-3-methylphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(3-methylphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-(pyridin-2-yl)methylidene]-2-[4-(trifluoromethyl)phenyl]acetohydrazide	-	Cryphonectria parasitica
(2S)-2-amino-N'-[(E)-cyclohexylmethylidene]-2-[4-(trifluoromethyl)phenyl]acetohydrazide	-	Cryphonectria parasitica
(S)-2-amino-2-(4-(trifluoromethyl)phenyl)acetohydrazide	-	Cryphonectria parasitica
(S)-2-amino-N'-(cyclopentylmethylene)-2-(4-(trifluoromethyl)phenyl)acetohydrazide trifluoro acetic acid	-	Cryphonectria parasitica
(S)-2-amino-N'-benzylidene-2-(4-(trifluoromethyl)phenyl)acetohydrazide	-	Cryphonectria parasitica
4-(trifluoromethyl)benzene-1-carboximidamide	-	Cryphonectria parasitica

Organism

Organism	UniProt	Comment	Textmining
Cryphonectria parasitica	P11838	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O	-	Cryphonectria parasitica	Abz-Thr-Ile-Nle + 4-nitro-Phe-Gln-Arg-NH2	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.085	-	pH and temperature not specified in the publication	Cryphonectria parasitica	(S)-2-amino-N'-(cyclopentylmethylene)-2-(4-(trifluoromethyl)phenyl)acetohydrazide trifluoro acetic acid
0.21	-	pH and temperature not specified in the publication	Cryphonectria parasitica	(S)-2-amino-N'-benzylidene-2-(4-(trifluoromethyl)phenyl)acetohydrazide

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Release 2023.1 (January 2023)