Literature summary for 3.4.23.16 extracted from

Hallengaerd, D.; Haller, B.K.; Petersson, S.; Boberg, A.; Maltais, A.K.; Isaguliants, M.; Wahren, B.; Brave, A.
Increased expression and immunogenicity of HIV-1 protease following inactivation of the enzymatic activity (2011), Vaccine, 29, 839-848.

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Protein Variants

Protein Variants	Comment	Organism
D25N	inactive	Human immunodeficiency virus 1
V82F/I84V	the mutation leads to resistance to standard antiretroviral drugs	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Synonyms

Synonyms	Comment	Organism
HIV-1 protease	-	Human immunodeficiency virus 1

Expression

Organism	Comment	Expression
Human immunodeficiency virus 1	the enzymatic inactivation of HIV-1 protease results in significantly increased in vitro expression	up

General Information

General Information	Comment	Organism
malfunction	inactivation of HIV-1 protease significantly increases the protease-specific humoral immune responses in mice	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)