Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(2-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(2-ethoxyethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(2-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(3,3-dimethylbutyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(3-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(3-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(4-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(4-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(4-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(cyclobutylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(cyclohexylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(cyclopentylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis(cyclopropylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-bis[2-(ethenyloxy)ethyl]-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-dibutyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-diethyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-diheptyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1,3-dihexyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-1-decyl-5,6-dihydroxy-3-nonyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxyethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylprop-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylpropyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-hydroxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-iodobenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbut-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-nitrobenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-hydroxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylbenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylpentyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(5-methylhexyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-1-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-2-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-2-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-3-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-4-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(2-methoxyethoxy)ethyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(morpholin-4-yl)ethyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(hydroxymethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(trifluoromethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-one | DMP323; enantiomer of DMP323 | Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(trifluoromethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-yn-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-dimethyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-dipentyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
4,7-dibenzyl-5,6-dihydroxy-1,3-dipropyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 protease | - |
Human immunodeficiency virus 1 |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000012 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-hydroxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000012 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-hydroxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000014 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(hydroxymethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000031 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-2-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000034 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000042 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-iodobenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00000089 | - |
4,7-dibenzyl-1,3-bis(3-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000013 | - |
4,7-dibenzyl-1,3-bis(cyclobutylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000014 | - |
4,7-dibenzyl-1,3-dibutyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000014 | - |
4,7-dibenzyl-1,3-bis(4-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000014 | - |
4,7-dibenzyl-1,3-bis(3-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000016 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000016 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-dipentyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000018 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbut-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000021 | - |
4,7-dibenzyl-1,3-bis(cyclopropylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000028 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-nitrobenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000003 | - |
4,7-dibenzyl-1,3-bis(3-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000003 | - |
1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000043 | - |
4,7-dibenzyl-1,3-bis(cyclopentylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000046 | - |
4,7-dibenzyl-1,3-dihexyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000052 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000052 | - |
4,7-dibenzyl-1,3-bis(4-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000058 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylbenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000071 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000071 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methylpentyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000072 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylprop-2-en-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000079 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-dipropyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0000098 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-3-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000012 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(3-methylbutyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000022 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-di(prop-2-yn-1-yl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000022 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[3-(trifluoromethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000027 | - |
4,7-dibenzyl-1,3-bis(4-bromobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00003 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(5-methylhexyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000034 | - |
4,7-dibenzyl-1,3-bis(2-fluorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000036 | - |
4,7-dibenzyl-1,3-bis(3,3-dimethylbutyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000037 | - |
4,7-dibenzyl-1,3-bis(cyclohexylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000049 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methylpropyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000051 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(trifluoromethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00006 | - |
4,7-dibenzyl-1,3-bis[2-(ethenyloxy)ethyl]-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000085 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-1-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.000089 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-4-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0001 | - |
4,7-dibenzyl-1,3-diethyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00011 | - |
4,7-dibenzyl-1-decyl-5,6-dihydroxy-3-nonyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00014 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(pyridin-2-ylmethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00016 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(4-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00024 | - |
4,7-dibenzyl-1,3-bis(2-chlorobenzyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00026 | - |
4,7-dibenzyl-1,3-diheptyl-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.00079 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxyethyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0011 | - |
4,7-dibenzyl-1,3-bis(2-ethoxyethyl)-5,6-dihydroxy-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0017 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[4-(hydroxymethyl)benzyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0019 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis(2-methoxybenzyl)-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.004 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(morpholin-4-yl)ethyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0058 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-dimethyl-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 | |
0.0078 | - |
4,7-dibenzyl-5,6-dihydroxy-1,3-bis[2-(2-methoxyethoxy)ethyl]-1,3-diazepan-2-one | - |
Human immunodeficiency virus 1 |