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Literature summary for 3.4.23.16 extracted from

  • Lambert-Niclot, S.; Flandre, P.; Malet, I.; Canestri, A.; Soulie, C.; Tubiana, R.; Brunet, C.; Wirden, M.; Katlama, C.; Calvez, V.; Marcelin, A.G.
    Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease (2008), J. Antimicrob. Chemother., 62, 905-908.
    View publication on PubMed

Application

Application Comment Organism
pharmacology mutations in the gag region NC-p1/TFP-p6/p6pol may influence the selection of darunavir resistance mutations. The I437T/V gag mutation that confers resistance to protease inhibitors reduces the selection of such mutations. Virus with L76V in protease or I437T/V in gag may be already resistant to darunavir Human immunodeficiency virus 1

Protein Variants

Protein Variants Comment Organism
L76V virus with mutation L76V in protease or I437T/V in gag may be already resistant to darunavir Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
darunavir mutations in the gag region NC-p1/TFP-p6/p6pol may influence the selection of darunavir resistance mutations. The I437T/V gag mutation that confers resistance to protease inhibitors reduces the selection of such mutations. Virus with L76V in protease or I437T/V in gag may be already resistant to darunavir Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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