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Literature summary for 3.4.23.16 extracted from

  • Das, A.; Prashar, V.; Mahale, S.; Serre, L.; Ferrer, J.L.; Hosur, M.V.
    Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates (2006), Proc. Natl. Acad. Sci. USA, 103, 18464-18469.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
three-dimensional structure of a bi-product complex between HIV-1 protease and the two cleavage product peptides AETF and YVDGAA. The structure, refined against synchrotron data to 1.65 A resolution, shows the occurrence of the cleavage reaction in the crystal, with the product peptides still held in the enzyme active site Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AETFYVDGAA + H2O
-
Human immunodeficiency virus 1 AETF + YVDGAA
-
?

Synonyms

Synonyms Comment Organism
HIV-1 protease
-
Human immunodeficiency virus 1