Application | Comment | Organism |
---|---|---|
medicine | insertions at positions 33 and 35 contribute to the viral resistance to most of the tested protease inhibitors. The structural analysis reveals local structural rearrangements in the flap region and in the substrate binding pockets. The enlargement of the HIV proteinase substrate binding site together with impaired flap dynamics could account for the weaker inhibitor binding by the insertion mutants. Amino acid insertions in the vicinity of the binding cleft represent a mechanism of HIV resistance development | Human immunodeficiency virus 1 |
Crystallization (Comment) | Organism |
---|---|
crystallization of variants of HIV proteinase with or without insertions at positions 33 and 35 | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | P03367 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 PR | - |
Human immunodeficiency virus 1 |