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Literature summary for 3.4.23.16 extracted from
- Human immunodeficiency virus 2 retropepsin (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. ; Rowlings, N. D. ; Woessner, J. F. , eds. ), 1, 154-157.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Human immunodeficiency virus 1 |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| substrate binding pocket structure analysis | Human immunodeficiency virus 1 |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | constuction of a hybrid comprising HIV-1 and HIV-2 retropepsin, overview | Human immunodeficiency virus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (hydroxyethyl)amide isostere | - |
Human immunodeficiency virus 1 |  |
| acetyl-pepstatin | - |
Human immunodeficiency virus 1 | |
| pepstatin A | - |
Human immunodeficiency virus 1 | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Human immunodeficiency virus 1 | |
| 0.064 | - |
YVSQNFPIVQNR | pH 4.7 | Human immunodeficiency virus 1 | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | self-processing of the immature progeny virus at the host cell membrane prior to virus budding, dimerization occurs before proteolytic cleavage | Human immunodeficiency virus 1 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| HIV-1 Gag-Pol polyprotein + H2O | site-specific proteolytic cleavage, protein precursors and peptides derived thereof | Human immunodeficiency virus 1 | ? | - |
? | |
| HIV-2 Gag-Pol poylprotein + H2O | site-specific proteolytic cleavage, protein precursors and peptides derived thereof | Human immunodeficiency virus 1 | ? | - |
? | |
| YVSQNFPIVQNR + H2O | synthetic peptide substrate based on the Ma/Ca cleavage site of HIV-1 Gag | Human immunodeficiency virus 1 | YVSQNF + PIVQNR | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | the HIV-2 retropepsin must form a homodimer in order to create a functional active site, dimerization occurs before proteolytic cleavage | Human immunodeficiency virus 1 |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV-1 proteinase | - |
Human immunodeficiency virus 1 |
| human immunodeficiency virus 1 retropepsin | - |
Human immunodeficiency virus 1 |
| More | the enzyme belongs to the peptidase family A2 | Human immunodeficiency virus 1 |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.7 | - |
assay at | Human immunodeficiency virus 1 |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000000075 | - |
(hydroxyethyl)amide isostere | - |
Human immunodeficiency virus 1 | |
| 0.0000014 | - |
pepstatin A | about, pH 4.7 | Human immunodeficiency virus 1 | |
| 0.00002 | - |
acetyl-pepstatin | pH 4.7, competitive versus YVSQNFPIVQNR | Human immunodeficiency virus 1 | |
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