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Literature summary for 3.4.23.16 extracted from

  • Guo, F.; Gabor, J.; Cen, S.; Hu, K.; Mouland, A.J.; Kleiman, L.
    Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase (2005), J. Biol. Chem., 280, 26018-26023.
    View publication on PubMed
Search for more literature for 3.4.23.16

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in HEK-293T cells, coexpression with tRNALys2 or tRNALys3, and with viral GagPol protein Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
lysyl-tRNA synthetase
-
 Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gag protein + H2O Human immunodeficiency virus 1 proteolytic cleavage in the host cell cytoplasm ?
-
 ?
Gag-Pol polyprotein + H2O Human immunodeficiency virus 1 proteolytic cleavage in the host cell cytoplasm ?
-
 ?
additional information Human immunodeficiency virus 1 the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 recombinant enzyme activity measurement by bioluminescence resonance energy transfer analysis Human immunodeficiency virus 1

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gag protein + H2O proteolytic cleavage in the host cell cytoplasm Human immunodeficiency virus 1 ?
-
 ?
Gag protein + H2O site-specific proteolytic cleavage of the protein precursor Human immunodeficiency virus 1 ?
-
 ?
Gag-Pol polyprotein + H2O proteolytic cleavage in the host cell cytoplasm Human immunodeficiency virus 1 ?
-
 ?
Gag-Pol polyprotein + H2O site-specific proteolytic cleavage of the protein precursor Human immunodeficiency virus 1 ?
-
 ?
additional information the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
HIV-1 protease
-
 Human immunodeficiency virus 1