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Literature summary for 3.4.23.16 extracted from

  • Louis, J.M.; Dyda, F.; Nashed, N.T.; Kimmel, A.R.; Davies, D.R.
    Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease (1998), Biochemistry, 37, 2105-2110.
    View publication on PubMed
Search for more literature for 3.4.23.16

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystallographic analysis of HIV-1 protease in complex with transframe peptide FLREDLAF and the tripeptide EDL Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
Arg-Arg with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Arg-Leu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Arg-Phe with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Glu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Glu-Asp with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Glu-Leu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Arg-Leu-Ala-Phe with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Asp-Asp
-
 Human immunodeficiency virus 1
Asp-Asp-Leu
-
 Human immunodeficiency virus 1
Asp-Asp-Phe
-
 Human immunodeficiency virus 1
Asp-Glu-Leu
-
 Human immunodeficiency virus 1
Asp-Leu-Ala-Phe
-
 Human immunodeficiency virus 1
FLREDLAF with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
GEDLAF with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Arg-Leu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Arg-Leu-Ala with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Arg-Phe with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Asn-Leu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Asp-Leu
-
 Human immunodeficiency virus 1
Glu-Asp-Leu-Ala
-
 Human immunodeficiency virus 1
Glu-Asp-Phe
-
 Human immunodeficiency virus 1
Glu-Glu-Leu with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Glu-Lys-Phe with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1
Phe-Asp-Asp-Phe with KARV-Nle-Phe(NO2)-EA-Nle-NH2 as substrate Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O
-
 Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-EA-Nle-NH2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
 Glu-Asp-Phe 25°C, pH 4.25 Human immunodeficiency virus 1
0.043
-
 Asp-Asp-Phe 25°C, pH 4.4 Human immunodeficiency virus 1
0.05
-
 Glu-Asp-Leu 25°C, pH 4.25 Human immunodeficiency virus 1
0.055
-
 Phe-Asp-Asp-Phe 25°C, pH 4.4 Human immunodeficiency virus 1
0.064
-
 GEDLAF 25°C, pH 4.25 Human immunodeficiency virus 1
0.098
-
 FLREDLAF 25°C, pH 4.25 Human immunodeficiency virus 1
0.14
-
 Asp-Asp-Leu 25°C, pH 4.25 Human immunodeficiency virus 1
0.16
-
 Glu-Asp-Leu-Ala 25°C, pH 4.25 Human immunodeficiency virus 1
0.23
-
 Asp-Glu-Leu 25°C, pH 4.25 Human immunodeficiency virus 1
0.27
-
 Asp-Leu-Ala-Phe 25°C, pH 4.25 Human immunodeficiency virus 1
0.31
-
 Glu-Glu-Leu 25°C, pH 4.25 Human immunodeficiency virus 1
0.97
-
 Asp-Asp 25°C, pH 4.25 Human immunodeficiency virus 1
2.01
-
 Glu-Lys-Phe 25°C, pH 4.25 Human immunodeficiency virus 1
3.07
-
 Glu-Asn-Leu 25°C, pH 4.25 Human immunodeficiency virus 1
3.36
-
 Arg-Glu-Asp 25°C, pH 4.25 Human immunodeficiency virus 1