Literature summary for 3.4.23.16 extracted from

Komai, T.; Yagi, R.; Suzuki-Sunagawa, H.; Ishikawa, Y.; Kasuya, A.; Miyamoto, S.; Handa, H.; Nishigaki, T.
Inhibition of HIV-1 protease by oxim derivatives (1997), Biochem. Biophys. Res. Commun., 230, 557-561.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(4-Chloro-phenyl)-propane-1,2-dione 1-oxime	slightly inhibitory	Human immunodeficiency virus 1
1-Chloro-3-(4-chloro-phenyl)-propan-2-one	slightly inhibitory	Human immunodeficiency virus 1
3,3,3-Tribromo-1-(2-methoxy-phenyl)-propane-1,2-dione 1-oxime	highly inhibitory	Human immunodeficiency virus 1
3,3-Dibromo-1-phenyl-propane-1,2-dione 1-oxime	highly inhibitory	Human immunodeficiency virus 1
3-Chloro-1-(4-chloro-phenyl)-propane-1,2-dione 1-oxime	highly inhibitory	Human immunodeficiency virus 1
additional information	oxim derivatives containing halogenomethylketone and phenyl moieties are specific HIV-1 protease inhibitors	Human immunodeficiency virus 1
pepstatin A	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-SQNYPIV-NH2 + H2O	-	Human immunodeficiency virus 1	Ac-SQNY + PIV-NH2	-	?

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Release 2023.1 (January 2023)