Literature summary for 3.4.23.15 extracted from

Ribeiro, A.A.; Palomino, Z.; Lima, M.P.; Souza, L.E.; Ferreira, D.S.; Pesquero, J.B.; Irigoyen, M.C.; Pesquero, J.L.; Casarini, D.E.
Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin (2015), J. Renin Angiotensin Aldosterone Syst., 16, 947-955 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensinogen + H2O	Mus musculus	-	angiotensin I + angiotensinogen propeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000047	-	wild type enzyme, at pH 7.5 and 37°C	Mus musculus
0.000064	-	enzyme from kidney of TGM (rTon) transgenic mice that express rat tonin, at pH 7.5 and 37°C	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensinogen + H2O	-	Mus musculus	angiotensin I + angiotensinogen propeptide	-	?
tetradecapeptide (AG(1-14)) + H2O	-	Mus musculus	?	-	?

Expression

Organism	Comment	Expression
Mus musculus	there is an increase of renin activity in the kidney of TGM(rTon) mice when compared to control animals	up

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Release 2023.1 (January 2023)