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Literature summary for 3.4.23.15 extracted from

  • Yan, Y.; Zhou, A.; Carrell, R.W.; Read, R.J.
    Structural basis for the specificity of renin-mediated angiotensinogen cleavage (2019), J. Biol. Chem., 294, 2353-2364 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with angiotensinogen, sitting drop vapor diffusion method, using 1.74 M (NH4)2SO4 and 0.1 M Tris, pH 7.6 Homo sapiens

Protein Variants

Protein Variants Comment Organism
D226A inactive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00076
-
angiotensinogen at pH 7.4 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00797
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
Superdex S200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293-EBNA cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O DRVYIHPFHLVIHNESTC Homo sapiens angiotensin I + angiotensinogen propeptide
-
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Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
angiotensinogen at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
250
-
angiotensinogen at pH 7.4 and 37°C Homo sapiens