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Literature summary for 3.4.23.15 extracted from

  • Fu, Y.; Alashi, A.M.; Young, J.F.; Therkildsen, M.; Aluko, R.E.
    Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin (2017), Int. J. Biol. Macromol., 101, 207-213 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Pro-Arg-Tyr mixed-type inhibition Homo sapiens
Trp-Gly mixed-type inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01937
-
 Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg at pH 8.0 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00797
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.013
-
 Pro-Arg-Tyr at pH 8.0 and 37°C Homo sapiens
0.14
-
 Trp-Gly at pH 8.0 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.09533
-
 at pH 8.0 and 37°C Homo sapiens Pro-Arg-Tyr
0.11234
-
 at pH 8.0 and 37°C Homo sapiens Trp-Gly