Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | direct renin inhibitor for the treatment of hypertension | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | Homo sapiens | renin catalyses the rate-limiting step in the system and has unique specificity for its substrate angiotensinogen | angiotensin I + angiotensinogen propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
juxtaglomerular cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | renin catalyses the rate-limiting step in the system and has unique specificity for its substrate angiotensinogen | Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | angiotensin II inhibits renin release from the juxtaglomerular cells in the kidney | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the renin-angiotensin-aldosterone system plays a key role in the regulation of blood volume, blood pressure, and cardiovascular and renal function | Homo sapiens |