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Literature summary for 3.4.23.15 extracted from
- Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren (2010), Eur. J. Clin. Pharmacol., 66, 497-502.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aliskiren | a renin inhibitor used in the treatment of hypertension. Rifampicin reduces the renin-inhibiting effect of aliskiren (plasma renin activity 24 h after aliskiren intake is 61% higher after treatment with rifampicin (600 mg once daily for 5 days)) | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? | |
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Release 2023.1 (January 2023)
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