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Literature summary for 3.4.23.15 extracted from

  • Park, P.J.; Ahn, C.B.; Jeon, Y.J.; Je, J.Y.
    Renin inhibition activity by chitooligosaccharides (2008), Bioorg. Med. Chem. Lett., 18, 2471-2474.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chitooligosaccharide chitooligosaccharides are competitive inhibitors of renin. Chitololigosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit the highest activity with IC50 value of 0.51 mg/ml and Km value of 0.28 mg/ml. Chitooligosaccharides from 90% deacetylated chitosan and with molecular weight below 1000 Da show an IC50 value of 0.59 mg/ml. Main binding sites of chitooligosaccharides are not S3-S1 pockets of renin. Interactions could be formed by the hydrogen bonding and/or the electrostatic interaction between the positively charged amide group at C2 postition and the carboxylates of the catalytic resiudues Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
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chitooligosaccharide chitooligosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit an Km value of 0.28 mg/ml Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
chitololigosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit an IC50 value of 0.51 mg/ml. Chitooligosaccharides from 90% deacetylated chitosan and with molecular weight below 1000 Da show an IC50 value of 0.59 mg/ml Homo sapiens chitooligosaccharide