Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chitooligosaccharide | chitooligosaccharides are competitive inhibitors of renin. Chitololigosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit the highest activity with IC50 value of 0.51 mg/ml and Km value of 0.28 mg/ml. Chitooligosaccharides from 90% deacetylated chitosan and with molecular weight below 1000 Da show an IC50 value of 0.59 mg/ml. Main binding sites of chitooligosaccharides are not S3-S1 pockets of renin. Interactions could be formed by the hydrogen bonding and/or the electrostatic interaction between the positively charged amide group at C2 postition and the carboxylates of the catalytic resiudues | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
chitooligosaccharide | chitooligosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit an Km value of 0.28 mg/ml | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
chitololigosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit an IC50 value of 0.51 mg/ml. Chitooligosaccharides from 90% deacetylated chitosan and with molecular weight below 1000 Da show an IC50 value of 0.59 mg/ml | Homo sapiens | chitooligosaccharide |