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Literature summary for 3.4.23.15 extracted from

  • Andrade, A.Q.; Casarini, D.E.; Schor, N.; Boim, M.A.
    Characterization of renin mRNA expression and enzyme activity in rat and mouse mesangial cells (2002), Braz. J. Med. Biol. Res., 35, 17-24.
    View publication on PubMed
Search for more literature for 3.4.23.15

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Mus musculus
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extracellular active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Rattus norvegicus
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-
intracellular active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Mus musculus 5622
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intracellular active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Rattus norvegicus 5622
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the main role of the enzyme is the intracellular generation of angiotensin ?
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 ?
additional information Rattus norvegicus the main role of the enzyme is the intracellular generation of angiotensin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
culture medium of mesangial cells, active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Mus musculus
-
culture medium of mesangial cells, active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Rattus norvegicus
-
mesangial cell active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Mus musculus
-
mesangial cell active renin is significantly higher in the cell lysate than in culture medium. Inactive prorenin is similar for the intracellular and extracellular compartments. Free active renin is the predominant form found in both cell compartments. Mesangial cells in culture are able to synthesize and translate renin mRNA probably as inactive prorenin which is mostly processed to active renin inside the cells. The cells secrete both forms of the enzyme but at lower level compared with intracellular content Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
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 Mus musculus angiotensin I + ?
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 ?
angiotensinogen + H2O
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 Rattus norvegicus angiotensin I + ?
-
 ?
additional information the main role of the enzyme is the intracellular generation of angiotensin Mus musculus ?
-
 ?
additional information the main role of the enzyme is the intracellular generation of angiotensin Rattus norvegicus ?
-
 ?