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Literature summary for 3.4.23.1 extracted from

  • Kageyama, T.
    Role of S1 loop residues in the substrate specificities of pepsin A and chymosin (2004), Biochemistry, 43, 15122-15130.
    View publication on PubMed
Search for more literature for 3.4.23.1

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
L291S replacement of a pepsin A-specific residue by a chymosin-specific one. Decrease in hydrolysis of peptides with hydrophobic/aromatic residues at P’1 site, increase in hydrolysis of peptides with charged residues at P’1 Homo sapiens
L291S/L298Q replacement of a pepsin A-specific residue by a chymosin-specific one. Decrease in hydrolysis of peptides with hydrophobic/aromatic residues at P’1 site, increase in hydrolysis of peptides with charged residues at P’1 Homo sapiens
L298Q replacement of a pepsin A-specific residue by a chymosin-specific one. Decrease in hydrolysis of peptides with hydrophobic/aromatic residues at P’1 site, increase in hydrolysis of peptides with charged residues at P’1 Homo sapiens
M289D replacement of a pepsin A-specific residue by a chymosin-specific one. Decrease in hydrolysis of peptides with hydrophobic/aromatic residues at P’1 site, increase in hydrolysis of peptides with charged residues at P’1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information preference for hydrophobic and aromatic residues at P’1 site of substrate Homo sapiens ?
-
 ?