Literature summary for 3.4.22.B79 extracted from

Zhu, W.Y.; Fu, S.H.; Wang, J.L.; He, Y.; Tang, Q.; Liang, G.D.
Effects of the nsP2-726 Pro mutation on infectivity and pathogenesis of Sindbis virus derived from a full-length infectious cDNA clone (2009), Virus Res., 142, 204-207.

Search for more literature for 3.4.22.B79

Protein Variants

Protein Variants	Comment	Organism
P726A	the mutant exhibits similar growth characteristics to the wild type BR-XJ160 in cultured cells, including cytopathic effects, plaque morphology and growth kinetics	Sindbis virus
P726L	the mutant shows no cytopathic effects or plaques after six passages through BHK-21 cells, although expression of XJ-160 virus-specific protein is detectable, the mutant produces no lethality or morbidity in suckling mice	Sindbis virus
P726S	the mutant shows reduced growth capacity in cultured cells and mouse brain, and intermediate neurovirulence	Sindbis virus
P726V	the mutant exhibits similar growth characteristics to the wild type BR-XJ160 in cultured cells, including cytopathic effects, plaque morphology and growth kinetics	Sindbis virus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
XJ-160 virus-specific protein + H2O	Sindbis virus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Sindbis virus	-	XJ-160 virus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
XJ-160 virus-specific protein + H2O	-	Sindbis virus	?	-	?

Synonyms

Synonyms	Comment	Organism
nonstructural protein 2	-	Sindbis virus
nsP2 protease	-	Sindbis virus

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Release 2023.1 (January 2023)