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Literature summary for 3.4.22.B73 extracted from

  • Di Bacco, A.; Ouyang, J.; Lee, H.Y.; Catic, A.; Ploegh, H.; Gill, G.
    The SUMO-specific protease SENP5 is required for cell division (2006), Mol. Cell. Biol., 26, 4489-4498.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C713S no isopeptidase activity, no desumoylation of (SUMO-1)-Ran GTPase-activating protein 1 conjugate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus localize predominantly to the nucleolus Homo sapiens 5730
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96HI0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate Homo sapiens SUMO-1 + Ran GTPase-activating protein 1
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate Homo sapiens SUMO-2 + Ran GTPase-activating protein 1
-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate Homo sapiens SUMO-3 + Ran GTPase-activating protein 1
-
?
SUMO-1 precursor + H2O the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro Homo sapiens SUMO-1 + His-Ser-Thr-Val
-
?
SUMO-3 precursor + H2O the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro Homo sapiens SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
?

General Information

General Information Comment Organism
malfunction knockdown of SENP5 leads to an increase in cells with more than one nucleus or aberrant nuclear structure consistent with defects in mitosis and cytokinesis Homo sapiens
physiological function SENP5 is required for cell division. SENP5 has nonredundant functions in vivo, likely due to distinct substrate specificities in SUMO maturation and deconjugation that are regulated by both the catalytic and noncatalytic domains of the enzyme Homo sapiens